Towards a functional definition of the mitochondrial human proteome

Mauro Fasano, Tiziana Alberio, Mohan Babu, Emma Lundberg, Andrea Urbani

Research output: Contribution to journalArticlepeer-review

Abstract

The mitochondrial human proteome project (mt-HPP) was initiated by the Italian HPP group as a part of both the chromosome-centric initiative (C-HPP) and the "biology and disease driven" initiative (B/D-HPP). In recent years several reports highlighted how mitochondrial biology and disease are regulated by specific interactions with non-mitochondrial proteins. Thus, it is of great relevance to extend our present view of the mitochondrial proteome not only to those proteins that are encoded by or transported to mitochondria, but also to their interactors that take part in mitochondria functionality. Here, we propose a graphical representation of the functional mitochondrial proteome by retrieving mitochondrial proteins from the NeXtProt database and adding to the network their interactors as annotated in the IntAct database. Notably, the network may represent a reference to map all the proteins that are currently being identified in mitochondrial proteomics studies.

Original languageEnglish
Pages (from-to)24-27
Number of pages4
JournalEuPA Open Proteomics
Volume10
DOIs
Publication statusPublished - Mar 1 2016

ASJC Scopus subject areas

  • Biochemistry

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