TY - JOUR
T1 - Towards a unified open access dataset of molecular interactions
AU - Porras, Pablo
AU - Barrera, Elisabet
AU - Bridge, Alan
AU - del-Toro, Noemi
AU - Cesareni, Gianni
AU - Duesbury, Margaret
AU - Hermjakob, Henning
AU - Iannuccelli, Marta
AU - Jurisica, Igor
AU - Kotlyar, Max
AU - Licata, Luana
AU - Lovering, Ruth C.
AU - Lynn, David J.
AU - Meldal, Birgit
AU - Nanduri, Bindu
AU - Paneerselvam, Kalpana
AU - Panni, Simona
AU - Pastrello, Chiara
AU - Pellegrini, Matteo
AU - Perfetto, Livia
AU - Rahimzadeh, Negin
AU - Ratan, Prashansa
AU - Ricard-Blum, Sylvie
AU - Salwinski, Lukasz
AU - Shirodkar, Gautam
AU - Shrivastava, Anjalia
AU - Orchard, Sandra
N1 - Funding Information:
The IntAct team at EMBL-EBI received funding from EMBL core funding, Open Targets (grant agreements OTAR-044 and OTAR02-048) and the Wellcome Trust (Biomedical Resources grant INVAR #3367). This work by UniProt was supported by the National Eye Institute (NEI), National Human Genome Research Institute (NHGRI), National Heart, Lung, and Blood Institute (NHLBI), National Institute on Aging (NIA), National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, National Institute of General Medical Sciences (NIGMS), National Cancer Institute (NCI) and National Institute of Mental Health (NIMH) of the National Institutes of Health under Award Number [U24HG007822] (the content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health) and EMBL core funding and Open Targets (grant agreements OTAR02-048). Support for IID was supplied in part by Ontario Research Fund (#34876), Natural Sciences Research Council (NSERC #203475) and Canada Foundation for Innovation (CFI #29272, #225404 and #33536). MatrixDB was supported by the Fondation pour la Recherche Médicale (grant DBI20141231336 to S.R.B.) and by the Institut Français de Bioinformatique (GlycoMatrixDB project-AAP IFB 2015 to S.R.B.). InnateDB was previously supported by Genome BC through the Pathogenomics of Innate Immunity (PI2) project and by the Foundation for the National Institutes of Health and the Canadian Institutes of Health Research under the Grand Challenges in Global Health Research Initiative [Grand Challenges ID: 419]. Further funding was also provided by AllerGen grants 12ASI1 and 12B&B2. D.J.L. is currently supported by an EMBL Australia Group Leader award. The Database of Interacting Proteins (DIP) was supported by National Institute of General Medical Sciences grant R01GM123126.
Publisher Copyright:
© 2020, The Author(s).
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - The International Molecular Exchange (IMEx) Consortium provides scientists with a single body of experimentally verified protein interactions curated in rich contextual detail to an internationally agreed standard. In this update to the work of the IMEx Consortium, we discuss how this initiative has been working in practice, how it has ensured database sustainability, and how it is meeting emerging annotation challenges through the introduction of new interactor types and data formats. Additionally, we provide examples of how IMEx data are being used by biomedical researchers and integrated in other bioinformatic tools and resources.
AB - The International Molecular Exchange (IMEx) Consortium provides scientists with a single body of experimentally verified protein interactions curated in rich contextual detail to an internationally agreed standard. In this update to the work of the IMEx Consortium, we discuss how this initiative has been working in practice, how it has ensured database sustainability, and how it is meeting emerging annotation challenges through the introduction of new interactor types and data formats. Additionally, we provide examples of how IMEx data are being used by biomedical researchers and integrated in other bioinformatic tools and resources.
UR - http://www.scopus.com/inward/record.url?scp=85097001859&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85097001859&partnerID=8YFLogxK
U2 - 10.1038/s41467-020-19942-z
DO - 10.1038/s41467-020-19942-z
M3 - Article
C2 - 33262342
AN - SCOPUS:85097001859
VL - 11
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 6144
ER -