Towards the use of baculovirus as a gene therapy vector

L. Pieroni, N. La Monica

Research output: Contribution to journalArticlepeer-review

Abstract

The use of baculovirus vectors for gene expression in mammalian cells is in continuous expansion. These vectors do not replicate in mammalian cells, do not cause a cytopathic effect upon infection and are able to carry large DNA inserts. Baculovirus vectors have been shown to transduce various cell types in vitro and in vivo with significant efficiency leading to stable gene expression. This review focuses on recent developments with baculovirus that highlight its potential use for new gene therapy strategies.

Original languageEnglish
Pages (from-to)464-467
Number of pages4
JournalCurrent Opinion in Molecular Therapeutics
Volume3
Issue number5
Publication statusPublished - 2001

Keywords

  • Baculovirus vectors
  • Gene therapy
  • Gene transfer

ASJC Scopus subject areas

  • Medicine(all)
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery
  • Genetics(clinical)

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