Abstract
A new methotrexate analog, 10-ethyl-10-deaza-aminopterin (10-EdAM), was found to induce a particular form of skin toxicity different than the skin rash reported to result from methotrexate. At histologic examination, it was found to be a toxic dermatitis that clinically most often first appears on the lower legs but can occur anywhere in the body, especially if treatment is continued. Nine cases are reported. A specific risk factor could not yet be identified. Discontinuation of 10-EdAM administration leads to complete healing; concomitant corticosteroid treatment also induces healing.
| Original language | English |
|---|---|
| Pages (from-to) | 1910-1913 |
| Number of pages | 4 |
| Journal | Cancer |
| Volume | 66 |
| Issue number | 9 |
| Publication status | Published - 1990 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Toxic dermatitis induced by 10-ethyl-10-deaza-aminopterin (10-EdAM), a novel antifolate. / Verweij, J.; Schornagel, J.; De Mulder, P.; Henzen-Logmans, S.; Cognetti, F.; Clavel, M.; Vermorken, J.
In: Cancer, Vol. 66, No. 9, 1990, p. 1910-1913.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Toxic dermatitis induced by 10-ethyl-10-deaza-aminopterin (10-EdAM), a novel antifolate
AU - Verweij, J.
AU - Schornagel, J.
AU - De Mulder, P.
AU - Henzen-Logmans, S.
AU - Cognetti, F.
AU - Clavel, M.
AU - Vermorken, J.
PY - 1990
Y1 - 1990
N2 - A new methotrexate analog, 10-ethyl-10-deaza-aminopterin (10-EdAM), was found to induce a particular form of skin toxicity different than the skin rash reported to result from methotrexate. At histologic examination, it was found to be a toxic dermatitis that clinically most often first appears on the lower legs but can occur anywhere in the body, especially if treatment is continued. Nine cases are reported. A specific risk factor could not yet be identified. Discontinuation of 10-EdAM administration leads to complete healing; concomitant corticosteroid treatment also induces healing.
AB - A new methotrexate analog, 10-ethyl-10-deaza-aminopterin (10-EdAM), was found to induce a particular form of skin toxicity different than the skin rash reported to result from methotrexate. At histologic examination, it was found to be a toxic dermatitis that clinically most often first appears on the lower legs but can occur anywhere in the body, especially if treatment is continued. Nine cases are reported. A specific risk factor could not yet be identified. Discontinuation of 10-EdAM administration leads to complete healing; concomitant corticosteroid treatment also induces healing.
UR - http://www.scopus.com/inward/record.url?scp=0025027160&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025027160&partnerID=8YFLogxK
M3 - Article
C2 - 2224785
AN - SCOPUS:0025027160
VL - 66
SP - 1910
EP - 1913
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 9
ER -