Toxic dermatitis induced by 10-ethyl-10-deaza-aminopterin (10-EdAM), a novel antifolate

J. Verweij, J. Schornagel, P. De Mulder, S. Henzen-Logmans, F. Cognetti, M. Clavel, J. Vermorken

Research output: Contribution to journalArticle

Abstract

A new methotrexate analog, 10-ethyl-10-deaza-aminopterin (10-EdAM), was found to induce a particular form of skin toxicity different than the skin rash reported to result from methotrexate. At histologic examination, it was found to be a toxic dermatitis that clinically most often first appears on the lower legs but can occur anywhere in the body, especially if treatment is continued. Nine cases are reported. A specific risk factor could not yet be identified. Discontinuation of 10-EdAM administration leads to complete healing; concomitant corticosteroid treatment also induces healing.

Original languageEnglish
Pages (from-to)1910-1913
Number of pages4
JournalCancer
Volume66
Issue number9
Publication statusPublished - 1990

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Folic Acid Antagonists
Poisons
Dermatitis
Methotrexate
Exanthema
Leg
Adrenal Cortex Hormones
Skin
edatrexate

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Verweij, J., Schornagel, J., De Mulder, P., Henzen-Logmans, S., Cognetti, F., Clavel, M., & Vermorken, J. (1990). Toxic dermatitis induced by 10-ethyl-10-deaza-aminopterin (10-EdAM), a novel antifolate. Cancer, 66(9), 1910-1913.

Toxic dermatitis induced by 10-ethyl-10-deaza-aminopterin (10-EdAM), a novel antifolate. / Verweij, J.; Schornagel, J.; De Mulder, P.; Henzen-Logmans, S.; Cognetti, F.; Clavel, M.; Vermorken, J.

In: Cancer, Vol. 66, No. 9, 1990, p. 1910-1913.

Research output: Contribution to journalArticle

Verweij, J, Schornagel, J, De Mulder, P, Henzen-Logmans, S, Cognetti, F, Clavel, M & Vermorken, J 1990, 'Toxic dermatitis induced by 10-ethyl-10-deaza-aminopterin (10-EdAM), a novel antifolate', Cancer, vol. 66, no. 9, pp. 1910-1913.
Verweij J, Schornagel J, De Mulder P, Henzen-Logmans S, Cognetti F, Clavel M et al. Toxic dermatitis induced by 10-ethyl-10-deaza-aminopterin (10-EdAM), a novel antifolate. Cancer. 1990;66(9):1910-1913.
Verweij, J. ; Schornagel, J. ; De Mulder, P. ; Henzen-Logmans, S. ; Cognetti, F. ; Clavel, M. ; Vermorken, J. / Toxic dermatitis induced by 10-ethyl-10-deaza-aminopterin (10-EdAM), a novel antifolate. In: Cancer. 1990 ; Vol. 66, No. 9. pp. 1910-1913.
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