Abstract
A new methotrexate analog, 10-ethyl-10-deaza-aminopterin (10-EdAM), was found to induce a particular form of skin toxicity different than the skin rash reported to result from methotrexate. At histologic examination, it was found to be a toxic dermatitis that clinically most often first appears on the lower legs but can occur anywhere in the body, especially if treatment is continued. Nine cases are reported. A specific risk factor could not yet be identified. Discontinuation of 10-EdAM administration leads to complete healing; concomitant corticosteroid treatment also induces healing.
Original language | English |
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Pages (from-to) | 1910-1913 |
Number of pages | 4 |
Journal | Cancer |
Volume | 66 |
Issue number | 9 |
Publication status | Published - 1990 |
ASJC Scopus subject areas
- Cancer Research
- Oncology