Toxic epidermal necrolysis successfully treated with etanercept

Emanuela Gubinelli, Flora Canzona, Tiziano Tonanzi, Desanka Raskovic, Biagio Didona

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Toxic epidermal necrolysis (TEN) is a rare and acute severe adverse reaction to drugs, characterised by massive apoptosis and widespread epidermal and mucosal detachment. Although no gold standard therapy exists, human i.v. immunoglobulins have recently been described as an effective treatment for this disease. We report a case of phenobarbital-induced TEN in a 59-year-old white woman where the epidermal detachment stopped 48 h after beginning the etanercept treatment with complete healing after 20 days. To the best of our knowledge, this is only the second reported case of TEN successfully treated with etanercept.

Original languageEnglish
Pages (from-to)150-153
Number of pages4
JournalJournal of Dermatology
Volume36
Issue number3
DOIs
Publication statusPublished - Mar 2009

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Stevens-Johnson Syndrome
Phenobarbital
Drug-Related Side Effects and Adverse Reactions
Immunoglobulins
Therapeutics
Apoptosis
Etanercept

Keywords

  • Cytokines in toxic epidermal necrolysis
  • Toxic epidermal necrolysis therapy
  • Tumor necrosis factor-α antagonists

ASJC Scopus subject areas

  • Dermatology

Cite this

Gubinelli, E., Canzona, F., Tonanzi, T., Raskovic, D., & Didona, B. (2009). Toxic epidermal necrolysis successfully treated with etanercept. Journal of Dermatology, 36(3), 150-153. https://doi.org/10.1111/j.1346-8138.2009.00616.x

Toxic epidermal necrolysis successfully treated with etanercept. / Gubinelli, Emanuela; Canzona, Flora; Tonanzi, Tiziano; Raskovic, Desanka; Didona, Biagio.

In: Journal of Dermatology, Vol. 36, No. 3, 03.2009, p. 150-153.

Research output: Contribution to journalArticle

Gubinelli, E, Canzona, F, Tonanzi, T, Raskovic, D & Didona, B 2009, 'Toxic epidermal necrolysis successfully treated with etanercept', Journal of Dermatology, vol. 36, no. 3, pp. 150-153. https://doi.org/10.1111/j.1346-8138.2009.00616.x
Gubinelli, Emanuela ; Canzona, Flora ; Tonanzi, Tiziano ; Raskovic, Desanka ; Didona, Biagio. / Toxic epidermal necrolysis successfully treated with etanercept. In: Journal of Dermatology. 2009 ; Vol. 36, No. 3. pp. 150-153.
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