Toxicity and cosmesis following partial breast irradiation consisting of 40 Gy in 10 daily fractions

Marco Trovo, Mario Roncadin, Jerry Polesel, Erica Piccoli, Mario Mileto, Elvia Micheli, Tiziana Perin, Antonino Carbone, Samuele Massarut, Mauro G. Trovo

Research output: Contribution to journalArticlepeer-review


Purpose: To assess the toxicity and cosmetic results in breast cancer patients undergoing adjuvant partial breast irradiation (PBI) to a total dose of 40Gy in 10 daily fractions (4Gy/fraction). Methods and materials: Patients affected by early-stage breast cancer were enrolled in this phase II trial. Patients had to be 60 years old and treated with breast conservative surgery for early stage (pT1-T2 pN0-N1a) invasive ductal carcinoma. Results: 77 patients were enrolled. Median follow-up was 18 months. The proposed schedule was well tolerated. One patient reported Grade 3 pain at the site of irradiation. Four (5%) patients experience Grade 2 erythema. Late Grade 2 and 1 fibrosis was observed in 3 (4%) and 14 (18%) patients, respectively. Cosmesis was judged "good/excellent" and "poor" in 75 (97%) and in 2 (3%) patients, respectively. Conclusions: 40Gy in 10 daily fractions, 4Gy/fraction, is a well tolerated regimen to deliver PBI.

Original languageEnglish
Pages (from-to)744-747
Number of pages4
Issue number5
Publication statusPublished - Oct 2013


  • Breast cancer
  • Cosmesis
  • Hypofractionation
  • Partial breast irradiation
  • Toxicity

ASJC Scopus subject areas

  • Surgery


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