TOSSICITA DEL CISPLATINO SOMMINISTRATO CON IDRATAZIONE DELLA DURATA DI UN'ORA E DIURESI FORZATA

Translated title of the contribution: Toxicity of cisplatinum administered with one-hour hydration and forced diuresis

M. Lopez, P. Papaldo, C. F. Perno

Research output: Contribution to journalArticle

Abstract

Three hundred and sixty one courses of cisplatinum were given in a one-hour regimen of hydration with mannitol-furosemide-induced diuresis to 86 patients with advanced malignant tumors. Doses were 75 mg/m2 iv every 3 weeks as a single agent in 80 patients and 60 mg/m2 iv in combination with adriamycin and VP-116-213 in 6 patients. Reversible nephrotoxicity occurred after 16 courses (4,43%) in 9 patients (10,46%). No patient developed an increase of BUN > 60 mg/dl or serum creatinine > 3.0 mg/dl. Cumulative renal damage, loss of hearing, and peripheral neuropathy were not observed. Nearly all patients experienced nausea and vomiting. Myelosuppression was mild.

Translated title of the contributionToxicity of cisplatinum administered with one-hour hydration and forced diuresis
Original languageItalian
Pages (from-to)207-213
Number of pages7
JournalClinica Terapeutica
Volume107
Issue number3
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Medicine(all)

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