Abstract
We report the toxicity of high-dose chemotherapy (HDC) based on etoposide, thiotepa and CY (ETC) in children with poor-prognosis Ewing's sarcoma family tumors (ESFTs). A total of 26 patients with high-risk ESFT (metastasis or axis localization or tumor volume 200 ml or necrosis 95%) were reviewed. The conditioning was based on etoposide (600 mg/m 2), thiotepa (750 mg/m 2) and CY (120 mg/kg) followed by autologous BM or PBSC rescue. The conditioning regimen was well tolerated, without any toxic deaths. The median time from transplant to a neutrophil count of 0.5 × 10 9 /l was 10 days (range 6-27) and 22.5 days (range 9-114) for a plt count of 50 × 10 9 /l. Oral mucositis was recorded in 20 patients, grade 1/2 in 19 and grade 3 in the last patient. Diarrhea grade 1/2 was recorded in four patients and grade 1/2 liver toxicity in four patients. Sepsis was documented in four cases and skin toxicity in three. Lung and tubular toxicity, respectively, were reported in one patient each. We conclude that the ETC regimen presented a limited and manageable toxicity. Further studies would confirm the role of ETC in high-risk ESFT.
| Original language | English |
|---|---|
| Pages (from-to) | 1274-1280 |
| Number of pages | 7 |
| Journal | Bone Marrow Transplantation |
| Volume | 45 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2010 |
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Keywords
- Ewings sarcoma family tumors
- high-dose chemotherapy
- thiotepa
ASJC Scopus subject areas
- Hematology
- Transplantation
Cite this
Toxicity of high-dose chemotherapy with etoposide, thiotepa and CY in treating poor-prognosis Ewing's sarcoma family tumors : The experience of the Bambino Ges Children's Hospital. / Ilari, I.; De Ioris, M. A.; Milano, G. M.; Pessolano, R.; De Lurentis, C.; De Sio, L.; Fidani, P.; Jenkner, A.; Cozza, R.
In: Bone Marrow Transplantation, Vol. 45, No. 8, 08.2010, p. 1274-1280.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Toxicity of high-dose chemotherapy with etoposide, thiotepa and CY in treating poor-prognosis Ewing's sarcoma family tumors
T2 - The experience of the Bambino Ges Children's Hospital
AU - Ilari, I.
AU - De Ioris, M. A.
AU - Milano, G. M.
AU - Pessolano, R.
AU - De Lurentis, C.
AU - De Sio, L.
AU - Fidani, P.
AU - Jenkner, A.
AU - Cozza, R.
PY - 2010/8
Y1 - 2010/8
N2 - We report the toxicity of high-dose chemotherapy (HDC) based on etoposide, thiotepa and CY (ETC) in children with poor-prognosis Ewing's sarcoma family tumors (ESFTs). A total of 26 patients with high-risk ESFT (metastasis or axis localization or tumor volume 200 ml or necrosis 95%) were reviewed. The conditioning was based on etoposide (600 mg/m 2), thiotepa (750 mg/m 2) and CY (120 mg/kg) followed by autologous BM or PBSC rescue. The conditioning regimen was well tolerated, without any toxic deaths. The median time from transplant to a neutrophil count of 0.5 × 10 9 /l was 10 days (range 6-27) and 22.5 days (range 9-114) for a plt count of 50 × 10 9 /l. Oral mucositis was recorded in 20 patients, grade 1/2 in 19 and grade 3 in the last patient. Diarrhea grade 1/2 was recorded in four patients and grade 1/2 liver toxicity in four patients. Sepsis was documented in four cases and skin toxicity in three. Lung and tubular toxicity, respectively, were reported in one patient each. We conclude that the ETC regimen presented a limited and manageable toxicity. Further studies would confirm the role of ETC in high-risk ESFT.
AB - We report the toxicity of high-dose chemotherapy (HDC) based on etoposide, thiotepa and CY (ETC) in children with poor-prognosis Ewing's sarcoma family tumors (ESFTs). A total of 26 patients with high-risk ESFT (metastasis or axis localization or tumor volume 200 ml or necrosis 95%) were reviewed. The conditioning was based on etoposide (600 mg/m 2), thiotepa (750 mg/m 2) and CY (120 mg/kg) followed by autologous BM or PBSC rescue. The conditioning regimen was well tolerated, without any toxic deaths. The median time from transplant to a neutrophil count of 0.5 × 10 9 /l was 10 days (range 6-27) and 22.5 days (range 9-114) for a plt count of 50 × 10 9 /l. Oral mucositis was recorded in 20 patients, grade 1/2 in 19 and grade 3 in the last patient. Diarrhea grade 1/2 was recorded in four patients and grade 1/2 liver toxicity in four patients. Sepsis was documented in four cases and skin toxicity in three. Lung and tubular toxicity, respectively, were reported in one patient each. We conclude that the ETC regimen presented a limited and manageable toxicity. Further studies would confirm the role of ETC in high-risk ESFT.
KW - Ewings sarcoma family tumors
KW - high-dose chemotherapy
KW - thiotepa
UR - http://www.scopus.com/inward/record.url?scp=77955565417&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955565417&partnerID=8YFLogxK
U2 - 10.1038/bmt.2009.353
DO - 10.1038/bmt.2009.353
M3 - Article
C2 - 20098456
AN - SCOPUS:77955565417
VL - 45
SP - 1274
EP - 1280
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
SN - 0268-3369
IS - 8
ER -