Toxicological and immune findings in workers exposed to pentachlorophenol pcp

Claudio Colosio, Marco Maroni, Nilma Barcellini, Pierluigi Meroni, Waniela Alcini, Antonio Colombi, Domenico Cavallo, Vito Foa

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Pentachlorophend (PCP) is a pesticide used worldwide in industrial and domestic applications. Data available on the effects of technical-grade PCP on the immune system are insufficient and equivocal; some data indicate inhibitory effects, whereas others suggest stimulating effects. This study was performed to evaluate toxicological and immune findings in 32 subjects who had prdonged exposure to PCP in a wood factory and in 37 controls. PCP concentrations were determined in plasma and urine of all subjects. Lymphocyte subsets of CDS, CDQ, and CDSpositiVe cells were evaluated, and the proliative response of peripheral blood mononuclear cells (PBM) to mitogens was assessed. The results sujgested the absence of major laboratory and clinical signs of PCPdependent immune deficiency. A weak effect of long-term exposure to PCP on the functional immune response could not be led out because of the finding of a decreased response to 5% PHA in the h&-exposure group. A weak effect against hepatme membrane was evidenced by the finding of raised serum concentration of glycochdic, taurodeoxycholii, and glycochenodeoxychdii acids in subjects dim& exposed to PCP for more than 10 y.

Original languageEnglish
Pages (from-to)81-88
Number of pages8
JournalArchives of Environmental Health
Issue number2
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health


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