Sodium valproate toxic effects are rare, but may in some instances be clinically relevant. There have been 14 cases of acute pancreatitis which recovered on drug withdrawal, except in 2 patients, who died. Subacute liver damage caused about 60 deaths. It is a peculiar form of hepatopathy, different from typical isiosyncratic drug reaction and it probably due to a direct action on energy metabolism. A subacute encephalopathy probably shares the same mechanism. In about 1% of children from women taking valproate during pregnancy, spina bifida is a possible malformation. Considering the widespread use of valproate, its toxic effects, compared to the therapeutic ones, are minimal. This information may help avoid dangerous consequences.
|Title of host publication||Bollettino - Lega Italiana contro l'Epilessia|
|Number of pages||6|
|Publication status||Published - 1988|
ASJC Scopus subject areas
- Clinical Neurology