Toxicological aspects of sodium valproate

G. Procaccianti, R. Riva, G. Zaccara, A. Baruzzi

Research output: Chapter in Book/Report/Conference proceedingChapter


Sodium valproate toxic effects are rare, but may in some instances be clinically relevant. There have been 14 cases of acute pancreatitis which recovered on drug withdrawal, except in 2 patients, who died. Subacute liver damage caused about 60 deaths. It is a peculiar form of hepatopathy, different from typical isiosyncratic drug reaction and it probably due to a direct action on energy metabolism. A subacute encephalopathy probably shares the same mechanism. In about 1% of children from women taking valproate during pregnancy, spina bifida is a possible malformation. Considering the widespread use of valproate, its toxic effects, compared to the therapeutic ones, are minimal. This information may help avoid dangerous consequences.

Original languageEnglish
Title of host publicationBollettino - Lega Italiana contro l'Epilessia
Number of pages6
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Clinical Neurology


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