Toxicological evaluation of the immune function of pesticide workers, a European wide assessment

P. Steerenberg, L. Van Amelsvoort, C. Colosio, E. Corsini, S. Fustinoni, T. Vergieva, C. Zaikov, S. Pennanen, J. Liesivuori, H. Van Loveren

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Abstract

In this study, the prolonged low-dose exposure of mixtures of pesticides has been examined on hematological parameters and components of the immune defense in occupationally exposed humans. This investigation was carried out in five field studies in: the Netherlands (flower bulb growers, mainly re-entry workers), Italy (vineyard workers), Finland (potato farmers), and Bulgaria (workers from a zineb factory and greenhouse workers). Immunotoxicity was studied by measuring hematological parameters, complement, immunoglobulins, lymphocyte subpopulations, natural killer cells, autoimmunity, and antibody responses to hepatitis B vaccination. The total study population consisted of 248 pesticide-exposed and 231 non-occupationally exposed workers. As a surrogate measure of pesticide exposure the urinary excretion of ethylenethiourea (ETU), the main metabolite ethylenebisdithiocarbamates was measured. A significantly higher level of ETU in occupationally exposed subjects compared with controls (2.7 ± 8.1 μg/g vs 0.5 ± 3.7 μg/g creatinine) was found. Statistically significant differences, albeit very low, were found for complement C3 and C4 and the immunoglobulin classes IgG4 and IgA. For complement and IgG4, the levels were slightly increased and the level of IgA was decreased. In the lymphocyte populations, the CD8 subpopulation was increased. No effects were found on autoimmune antibodies and antibody response to hepatitis vaccination. In conclusion, pesticide exposure under various work place conditions in Europe was associated only with some subtle effects on the immune system, which may suggest that occupational exposure to pesticides does not influence the immunologic system in a clinically significant fashion, and does not pose a significant health risk to the exposed subjects.

Original languageEnglish
Pages (from-to)701-707
Number of pages7
JournalHuman and Experimental Toxicology
Volume27
Issue number9
DOIs
Publication statusPublished - Sep 2008

Fingerprint

Pesticides
Toxicology
Ethylenethiourea
Lymphocytes
Immunoglobulin A
Antibody Formation
Antibodies
Zineb
Vaccination
Immunoglobulin G
Complement C4
Bulgaria
Complement C3
Immunoglobulin Isotypes
Immune system
Health risks
Reentry
Greenhouses
Lymphocyte Subsets
Occupational Exposure

Keywords

  • Epidemiology
  • Multicentre study
  • Pesticides

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Steerenberg, P., Van Amelsvoort, L., Colosio, C., Corsini, E., Fustinoni, S., Vergieva, T., ... Van Loveren, H. (2008). Toxicological evaluation of the immune function of pesticide workers, a European wide assessment. Human and Experimental Toxicology, 27(9), 701-707. https://doi.org/10.1177/0960327108095993

Toxicological evaluation of the immune function of pesticide workers, a European wide assessment. / Steerenberg, P.; Van Amelsvoort, L.; Colosio, C.; Corsini, E.; Fustinoni, S.; Vergieva, T.; Zaikov, C.; Pennanen, S.; Liesivuori, J.; Van Loveren, H.

In: Human and Experimental Toxicology, Vol. 27, No. 9, 09.2008, p. 701-707.

Research output: Contribution to journalArticle

Steerenberg, P, Van Amelsvoort, L, Colosio, C, Corsini, E, Fustinoni, S, Vergieva, T, Zaikov, C, Pennanen, S, Liesivuori, J & Van Loveren, H 2008, 'Toxicological evaluation of the immune function of pesticide workers, a European wide assessment', Human and Experimental Toxicology, vol. 27, no. 9, pp. 701-707. https://doi.org/10.1177/0960327108095993
Steerenberg, P. ; Van Amelsvoort, L. ; Colosio, C. ; Corsini, E. ; Fustinoni, S. ; Vergieva, T. ; Zaikov, C. ; Pennanen, S. ; Liesivuori, J. ; Van Loveren, H. / Toxicological evaluation of the immune function of pesticide workers, a European wide assessment. In: Human and Experimental Toxicology. 2008 ; Vol. 27, No. 9. pp. 701-707.
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