Toxoplasma cyst detection in Piringer-Kuchinka lymphadenitis. Report of two cases and literature review

Luca Ventura; Magda Zanelli; Maurizio Zizzo; Francesca Sanguedolce; Giovanni Martino; Carolina Castro Ruiz; Valerio Annessi; Stefano Ascani

doi:10.32074/1591-951X-139

Toxoplasma cyst detection in Piringer-Kuchinka lymphadenitis. Report of two cases and literature review

Luca Ventura, Magda Zanelli, Maurizio Zizzo, Francesca Sanguedolce, Giovanni Martino, Carolina Castro Ruiz, Valerio Annessi, Stefano Ascani

Research output: Contribution to journal › Review article › peer-review

Abstract

The diagnosis of acute toxoplasmic lymphadenitis is traditionally based on the combination of lymph node excisional biopsy with specific tests. The classic triad (marked follicular hyperplasia, small irregular clusters of epithelioid histiocytes in germinal centers, and sinusoidal distension by monocytoid B lymphocytes) is considered diagnostic of the so-called Piringer-Kuchinka lymphadenitis. Toxoplasma gondii organisms have been exceptionally disclosed in such histopathological setting, establishing the diagnosis of toxoplasmic lymphadenitis. Two cases of Piringer-Kuchinka lymphadenitis with toxoplasma cyst demonstration are reported, along with a complete review of the literature.

Original language	English
Pages (from-to)	126-130
Number of pages	5
Journal	Pathologica
Volume	113
Issue number	2
DOIs	https://doi.org/10.32074/1591-951X-139
Publication status	Published - Apr 2021

Keywords

Bradyzoites
Follicular hyperplasia
Toxoplasma cyst
Toxoplasma gondii
Toxoplasmic lymphadenitis

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.32074/1591-951X-139

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Toxoplasma cyst detection in Piringer-Kuchinka lymphadenitis. Report of two cases and literature review. / Ventura, Luca; Zanelli, Magda ; Zizzo, Maurizio; Sanguedolce, Francesca; Martino, Giovanni; Ruiz, Carolina Castro; Annessi, Valerio; Ascani, Stefano.

In: Pathologica, Vol. 113, No. 2, 04.2021, p. 126-130.

Research output: Contribution to journal › Review article › peer-review

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abstract = "The diagnosis of acute toxoplasmic lymphadenitis is traditionally based on the combination of lymph node excisional biopsy with specific tests. The classic triad (marked follicular hyperplasia, small irregular clusters of epithelioid histiocytes in germinal centers, and sinusoidal distension by monocytoid B lymphocytes) is considered diagnostic of the so-called Piringer-Kuchinka lymphadenitis. Toxoplasma gondii organisms have been exceptionally disclosed in such histopathological setting, establishing the diagnosis of toxoplasmic lymphadenitis. Two cases of Piringer-Kuchinka lymphadenitis with toxoplasma cyst demonstration are reported, along with a complete review of the literature.",

keywords = "Bradyzoites, Follicular hyperplasia, Toxoplasma cyst, Toxoplasma gondii, Toxoplasmic lymphadenitis",

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AU - Ventura, Luca

AU - Zanelli, Magda

AU - Zizzo, Maurizio

AU - Sanguedolce, Francesca

AU - Martino, Giovanni

AU - Ruiz, Carolina Castro

AU - Annessi, Valerio

AU - Ascani, Stefano

PY - 2021/4

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AB - The diagnosis of acute toxoplasmic lymphadenitis is traditionally based on the combination of lymph node excisional biopsy with specific tests. The classic triad (marked follicular hyperplasia, small irregular clusters of epithelioid histiocytes in germinal centers, and sinusoidal distension by monocytoid B lymphocytes) is considered diagnostic of the so-called Piringer-Kuchinka lymphadenitis. Toxoplasma gondii organisms have been exceptionally disclosed in such histopathological setting, establishing the diagnosis of toxoplasmic lymphadenitis. Two cases of Piringer-Kuchinka lymphadenitis with toxoplasma cyst demonstration are reported, along with a complete review of the literature.

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Toxoplasma cyst detection in Piringer-Kuchinka lymphadenitis. Report of two cases and literature review

Abstract

Keywords

ASJC Scopus subject areas

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