Toxoplasma gondii: a new diagnostic approach based on the specific binding of erythrocytes to lymphoid cells

E. Magliulo, E. Concia, M. Azzini, D. Bonizzoni, D. Scevola

Research output: Contribution to journalArticle

Abstract

Red blood cells coated with toxoplasma antigen were bound to surface receptors, possibly of Ig nature, on lymphoid cells which appeared in the spleen of albino rats a few days after intraperitoneal injection of living T. gondii of the RH strain. Antigen binding cells appeared before specific antibody, then declined in number, while the antibody response was progressing. Available information stresses the identity of antigen binding cells with precursors of antibody forming cells, thus pointing to the early occurrence of the immunocytoadherence phenomenon in the immune response. The applicability of these concepts to the field of human toxoplasmosis was proved by the demonstration of circulating lymphocytes specifically binding toxoplasma antigen early in the course of human toxoplasmic lymphadenitis and only in relation to active disease, thus providing an interesting approach to the early diagnosis and the detection of the active state of the disease. Possible clinical implications are discussed.

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalExperimental Parasitology
Volume39
Issue number1
DOIs
Publication statusPublished - 1976

Fingerprint

Toxoplasma
Erythrocytes
Lymphocytes
Antigens
Rosette Formation
Lymphadenitis
Antibodies
Toxoplasmosis
Intraperitoneal Injections
Antibody Formation
Early Diagnosis
Spleen

ASJC Scopus subject areas

  • Immunology
  • Parasitology
  • Infectious Diseases

Cite this

Toxoplasma gondii : a new diagnostic approach based on the specific binding of erythrocytes to lymphoid cells. / Magliulo, E.; Concia, E.; Azzini, M.; Bonizzoni, D.; Scevola, D.

In: Experimental Parasitology, Vol. 39, No. 1, 1976, p. 143-149.

Research output: Contribution to journalArticle

Magliulo, E. ; Concia, E. ; Azzini, M. ; Bonizzoni, D. ; Scevola, D. / Toxoplasma gondii : a new diagnostic approach based on the specific binding of erythrocytes to lymphoid cells. In: Experimental Parasitology. 1976 ; Vol. 39, No. 1. pp. 143-149.
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