Toxoplasma gondii: in vivo and in vitro immunological and ultrastructural patterns of a human low virulent strain.

G. Filice, G. Carnevale, P. Lanzarini, F. Castelli, R. Benzi-Cipelli, G. Gorini, G. Carosi, E. G. Rondanelli

Research output: Contribution to journalArticlepeer-review

Abstract

The AA. analyze the ultrastructural and immunological patterns of a low virulent strain of T. gondii cultured in vitro on A-9 cells line (PV-H1C-83). The tissue culture method described here is highly recommended to study the immunological aspects of experimental toxoplasmosis. Biological tests' results and the time courses of serological tests are also similar to those obtained from mice infected with cerebral tissue containing cysts. The low virulent strain (PV-H1C-83), when cultured in vitro, is able to induce the formation of large parasitophorous vacuoles, in which the EM investigation shows a typical cyst wall enveloping numerous bradyzoites.

Original languageEnglish
Pages (from-to)119-125
Number of pages7
JournalBollettino dell'Istituto Sieroterapico Milanese
Volume64
Issue number2
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Immunology

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