Toxoplasma gondii virulence: changing pattern under different maintenance conditions.

P. Olliaro, A. Marchetti, A. Regazzetti, M. Fabbi, G. Gorini

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Toxoplasma gondii parasites were isolated in vitro and in vivo from a hare that had died of disseminated toxoplasmosis. Intraperitoneal inoculation of either homogenate of hare organs or parasites isolated on culture produced chronic infection in mice. However, a progressive increase of virulence following subsequent mouse-to-mouse transfections was observed. These findings suggest that host-parasite interaction plays a major role in determining the degree of pathogenicity, and that in vitro and in vivo isolation, if not followed by subsequent passages, may fail to reveal major differences in virulence between isolates.

Original languageEnglish
Pages (from-to)17-19
Number of pages3
JournalParassitologia
Volume35
Issue number1-3
Publication statusPublished - Dec 1993

Fingerprint

Toxoplasma
Hares
Virulence
Maintenance
Parasites
Host-Parasite Interactions
Toxoplasmosis
Transfection
Infection
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Olliaro, P., Marchetti, A., Regazzetti, A., Fabbi, M., & Gorini, G. (1993). Toxoplasma gondii virulence: changing pattern under different maintenance conditions. Parassitologia, 35(1-3), 17-19.

Toxoplasma gondii virulence : changing pattern under different maintenance conditions. / Olliaro, P.; Marchetti, A.; Regazzetti, A.; Fabbi, M.; Gorini, G.

In: Parassitologia, Vol. 35, No. 1-3, 12.1993, p. 17-19.

Research output: Contribution to journalArticle

Olliaro, P, Marchetti, A, Regazzetti, A, Fabbi, M & Gorini, G 1993, 'Toxoplasma gondii virulence: changing pattern under different maintenance conditions.', Parassitologia, vol. 35, no. 1-3, pp. 17-19.
Olliaro P, Marchetti A, Regazzetti A, Fabbi M, Gorini G. Toxoplasma gondii virulence: changing pattern under different maintenance conditions. Parassitologia. 1993 Dec;35(1-3):17-19.
Olliaro, P. ; Marchetti, A. ; Regazzetti, A. ; Fabbi, M. ; Gorini, G. / Toxoplasma gondii virulence : changing pattern under different maintenance conditions. In: Parassitologia. 1993 ; Vol. 35, No. 1-3. pp. 17-19.
@article{2588d06c9e174cb0b11d5810159f20e7,
title = "Toxoplasma gondii virulence: changing pattern under different maintenance conditions.",
abstract = "Toxoplasma gondii parasites were isolated in vitro and in vivo from a hare that had died of disseminated toxoplasmosis. Intraperitoneal inoculation of either homogenate of hare organs or parasites isolated on culture produced chronic infection in mice. However, a progressive increase of virulence following subsequent mouse-to-mouse transfections was observed. These findings suggest that host-parasite interaction plays a major role in determining the degree of pathogenicity, and that in vitro and in vivo isolation, if not followed by subsequent passages, may fail to reveal major differences in virulence between isolates.",
author = "P. Olliaro and A. Marchetti and A. Regazzetti and M. Fabbi and G. Gorini",
year = "1993",
month = "12",
language = "English",
volume = "35",
pages = "17--19",
journal = "Parassitologia",
issn = "0048-2951",
publisher = "Lombardo Editore",
number = "1-3",

}

TY - JOUR

T1 - Toxoplasma gondii virulence

T2 - changing pattern under different maintenance conditions.

AU - Olliaro, P.

AU - Marchetti, A.

AU - Regazzetti, A.

AU - Fabbi, M.

AU - Gorini, G.

PY - 1993/12

Y1 - 1993/12

N2 - Toxoplasma gondii parasites were isolated in vitro and in vivo from a hare that had died of disseminated toxoplasmosis. Intraperitoneal inoculation of either homogenate of hare organs or parasites isolated on culture produced chronic infection in mice. However, a progressive increase of virulence following subsequent mouse-to-mouse transfections was observed. These findings suggest that host-parasite interaction plays a major role in determining the degree of pathogenicity, and that in vitro and in vivo isolation, if not followed by subsequent passages, may fail to reveal major differences in virulence between isolates.

AB - Toxoplasma gondii parasites were isolated in vitro and in vivo from a hare that had died of disseminated toxoplasmosis. Intraperitoneal inoculation of either homogenate of hare organs or parasites isolated on culture produced chronic infection in mice. However, a progressive increase of virulence following subsequent mouse-to-mouse transfections was observed. These findings suggest that host-parasite interaction plays a major role in determining the degree of pathogenicity, and that in vitro and in vivo isolation, if not followed by subsequent passages, may fail to reveal major differences in virulence between isolates.

UR - http://www.scopus.com/inward/record.url?scp=0027876444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027876444&partnerID=8YFLogxK

M3 - Article

C2 - 8065815

AN - SCOPUS:0027876444

VL - 35

SP - 17

EP - 19

JO - Parassitologia

JF - Parassitologia

SN - 0048-2951

IS - 1-3

ER -