Abstract
Toxoplasma gondii parasites were isolated in vitro and in vivo from a hare that had died of disseminated toxoplasmosis. Intraperitoneal inoculation of either homogenate of hare organs or parasites isolated on culture produced chronic infection in mice. However, a progressive increase of virulence following subsequent mouse-to-mouse transfections was observed. These findings suggest that host-parasite interaction plays a major role in determining the degree of pathogenicity, and that in vitro and in vivo isolation, if not followed by subsequent passages, may fail to reveal major differences in virulence between isolates.
| Original language | English |
|---|---|
| Pages (from-to) | 17-19 |
| Number of pages | 3 |
| Journal | Parassitologia |
| Volume | 35 |
| Issue number | 1-3 |
| Publication status | Published - Dec 1993 |
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ASJC Scopus subject areas
- Immunology and Microbiology(all)
Cite this
Toxoplasma gondii virulence : changing pattern under different maintenance conditions. / Olliaro, P.; Marchetti, A.; Regazzetti, A.; Fabbi, M.; Gorini, G.
In: Parassitologia, Vol. 35, No. 1-3, 12.1993, p. 17-19.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Toxoplasma gondii virulence
T2 - changing pattern under different maintenance conditions.
AU - Olliaro, P.
AU - Marchetti, A.
AU - Regazzetti, A.
AU - Fabbi, M.
AU - Gorini, G.
PY - 1993/12
Y1 - 1993/12
N2 - Toxoplasma gondii parasites were isolated in vitro and in vivo from a hare that had died of disseminated toxoplasmosis. Intraperitoneal inoculation of either homogenate of hare organs or parasites isolated on culture produced chronic infection in mice. However, a progressive increase of virulence following subsequent mouse-to-mouse transfections was observed. These findings suggest that host-parasite interaction plays a major role in determining the degree of pathogenicity, and that in vitro and in vivo isolation, if not followed by subsequent passages, may fail to reveal major differences in virulence between isolates.
AB - Toxoplasma gondii parasites were isolated in vitro and in vivo from a hare that had died of disseminated toxoplasmosis. Intraperitoneal inoculation of either homogenate of hare organs or parasites isolated on culture produced chronic infection in mice. However, a progressive increase of virulence following subsequent mouse-to-mouse transfections was observed. These findings suggest that host-parasite interaction plays a major role in determining the degree of pathogenicity, and that in vitro and in vivo isolation, if not followed by subsequent passages, may fail to reveal major differences in virulence between isolates.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027876444&partnerID=8YFLogxK
M3 - Article
C2 - 8065815
AN - SCOPUS:0027876444
VL - 35
SP - 17
EP - 19
JO - Parassitologia
JF - Parassitologia
SN - 0048-2951
IS - 1-3
ER -