Toxoplasma gondii virulence: changing pattern under different maintenance conditions.

P. Olliaro, A. Marchetti, A. Regazzetti, M. Fabbi, G. Gorini

Research output: Contribution to journalArticlepeer-review


Toxoplasma gondii parasites were isolated in vitro and in vivo from a hare that had died of disseminated toxoplasmosis. Intraperitoneal inoculation of either homogenate of hare organs or parasites isolated on culture produced chronic infection in mice. However, a progressive increase of virulence following subsequent mouse-to-mouse transfections was observed. These findings suggest that host-parasite interaction plays a major role in determining the degree of pathogenicity, and that in vitro and in vivo isolation, if not followed by subsequent passages, may fail to reveal major differences in virulence between isolates.

Original languageEnglish
Pages (from-to)17-19
Number of pages3
Issue number1-3
Publication statusPublished - Dec 1993

ASJC Scopus subject areas

  • Immunology and Microbiology(all)


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