TP53 codon 72 polymorphism does not affect risk of cervical cancer in patients from The Gambia

G. Tanara, C. Falugi, A. Cesario, S. Margaritora, Patrizia Russo, A. Cosimi

Research output: Contribution to journalArticle

Abstract

Aims: A case-control study was performed to investigate the relationship between cervical cancer and TP53 polymorphism at codon 72 in young black African women from The Gambia. Materials and methods: The TP53 polymorphism at codon 72 was examined by PCR amplification and SSCP analysis in 40 patients with primary cervical cancer and in 20 healthy women of the same age and from the same geographical area. The occurrence of TP53 polymorphism in combination with the HPV-16 E6 genotype (assayed by PCR) was evaluated. Results: The distribution of TP53 genotypes in cervical cancer patients and in the control group was not statistically different (p=0.45) and homozygosity for argine at residue 72 was not associated with cervical cancer (odds ratio: 1.24; 95% confidence interval 0.21-9.16). Similarly, a different genotype distribution, cervical cancer and presence of HPV-16 E6 were not observed. Conclusions: These results cannot rule out an association between TP53 polymorphism at codon 72, HPV infection and the etiology of cervical cancer in this population sample.

Original languageEnglish
Pages (from-to)280-283
Number of pages4
JournalInternational Journal of Biological Markers
Volume18
Issue number4
Publication statusPublished - Oct 2003

Keywords

  • Black African women
  • Cervical cancer
  • Codon 72
  • HPV-16 E6
  • TP53 polymorphism

ASJC Scopus subject areas

  • Biochemistry
  • Immunology

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