TP53 codon 72 polymorphism in patients with chronic myeloid leukemia

Research output: Contribution to journalArticlepeer-review

Abstract

A single nucleotide polymorphism at TP53 codon 72 means that two alleles exist: A1 (proline residue, Pro72) and A2 (arginine residue, Arg72). The Pro72 variant of p53 has a lower apoptotic potential. We found that allele A1 was more frequent in patients with chronic myeloid leukemia (CML) than in controls, and among CML patients who had no cytogenetic response than among responders.

Original languageEnglish
Pages (from-to)868-869
Number of pages2
JournalHaematologica
Volume89
Issue number7
Publication statusPublished - Jul 2004

Keywords

  • Chronic myeloid leukemia
  • Imatinib mesylate
  • Polymorphism
  • TP53

ASJC Scopus subject areas

  • Hematology

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