TY - JOUR
T1 - TP53 codon 72 polymorphism may predict early tumour progression in paediatric pilocytic astrocytoma
AU - Mascelli, Samantha
AU - Nozza, Paolo
AU - Jones, David T W
AU - Colin, Carole
AU - Pistorio, Angela
AU - Milanaccio, Claudia
AU - Ravegnani, Marcello
AU - Consales, Alessandro
AU - Witt, Olaf
AU - Morana, Giovanni
AU - Cama, Armando
AU - Capra, Valeria
AU - Biassoni, Roberto
AU - Pfister, Stefan M.
AU - Figarella-Branger, Dominique
AU - Garrè, Maria Luisa
AU - Raso, Alessandro
PY - 2016
Y1 - 2016
N2 - Pilocytic astrocytoma and ganglioglioma may occur in inaccessible or surgically difficult areas. In case of incomplete resection, the availability of biological predictors of tumour progression could be particularly important. To this end, an analysis of p53 codon 72 polymorphism and assessment of its role as prognostic marker were performed. The status of the p53 Arg72Pro polymorphism was evaluated by pyrosequencing method in a multicenter cohort of 170 paediatric patients. Genotype/phenotype associations were investigated either by means of bivariate or multivariate analyses. In the partially resected pilocytic astrocytomas, the Arg/Arg variant predicts early tumour progression (median survival time: 23.1 months) and is associated with poor event-free survival (p value = 0.0009). This finding remains true also in case of adjuvant therapies, with a 5-year event-free survival of 30.6% for cases with Arg/Arg variant vs. 78.7% for those with other genotypes. There is no association between ganglioglioma and the polymorphism. The assessment of Arg/Arg variant could improve the management of pilocytic astrocytoma. TP53 codon 72 analysis could distinguish low-risk cases, in which surgery could be conservative, from high-risk cases needing an aggressive surgery plan.
AB - Pilocytic astrocytoma and ganglioglioma may occur in inaccessible or surgically difficult areas. In case of incomplete resection, the availability of biological predictors of tumour progression could be particularly important. To this end, an analysis of p53 codon 72 polymorphism and assessment of its role as prognostic marker were performed. The status of the p53 Arg72Pro polymorphism was evaluated by pyrosequencing method in a multicenter cohort of 170 paediatric patients. Genotype/phenotype associations were investigated either by means of bivariate or multivariate analyses. In the partially resected pilocytic astrocytomas, the Arg/Arg variant predicts early tumour progression (median survival time: 23.1 months) and is associated with poor event-free survival (p value = 0.0009). This finding remains true also in case of adjuvant therapies, with a 5-year event-free survival of 30.6% for cases with Arg/Arg variant vs. 78.7% for those with other genotypes. There is no association between ganglioglioma and the polymorphism. The assessment of Arg/Arg variant could improve the management of pilocytic astrocytoma. TP53 codon 72 analysis could distinguish low-risk cases, in which surgery could be conservative, from high-risk cases needing an aggressive surgery plan.
KW - Low-grade gliomas
KW - Paediatric
KW - Pilocytic astrocytoma
KW - Polymorphism
KW - TP53
UR - http://www.scopus.com/inward/record.url?scp=84982792234&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84982792234&partnerID=8YFLogxK
U2 - 10.18632/oncotarget.10295
DO - 10.18632/oncotarget.10295
M3 - Article
AN - SCOPUS:84982792234
VL - 7
SP - 47918
EP - 47926
JO - Oncotarget
JF - Oncotarget
SN - 1949-2553
IS - 30
ER -