Tp53-gene transfer induces hypersensitivity to low doses of X-rays in glioblastoma cells: A strategy to convert a radio-resistant phenotype into a radiosensitive one

Paola D. Avenia, Alessandro Porrello, Marco Berardo, Marco D. Angelo, Silvia Soddu, Giorgio Arcangeli, Ada Sacchi, Gabriella D. Orazi

Research output: Contribution to journalArticlepeer-review

Abstract

Tp53 is frequently mutated or inactivated in glioblastomas. Due to the impairment of p53 activity, glioblastomas show a high degree of radioresistance. In an attempt to convert the radioresistant phenotype to a more radiosensitive one, we evaluated the efficacy of the combination of Adp53 gene transfer and X-ray irradiation. The combination of Adp53, at low multiplicity in order to mimic the low in vivo efficiency of virus-mediated gene delivery, with X-ray irradiation resulted in a marked decrease of glioblastoms cell survival. Interestingly, Adp53 was able to induce low dose (

Original languageEnglish
Pages (from-to)102-112
Number of pages11
JournalCancer Letters
Volume231
Issue number1
DOIs
Publication statusPublished - Jan 8 2006

Keywords

  • Adp53
  • Brain tumors
  • Clonogenic survival
  • Hyper-radiosensitivity
  • Radiotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Fingerprint

Dive into the research topics of 'Tp53-gene transfer induces hypersensitivity to low doses of X-rays in glioblastoma cells: A strategy to convert a radio-resistant phenotype into a radiosensitive one'. Together they form a unique fingerprint.

Cite this