TPN-related digestive complications in critically ill patients

Giovambattista Forte, D. Boggio Bertinet, A. Federico, A. Guglielmi, C. Loguercio, S. Mazzuoli, M. Merli, A. Palmo, C. Panella, L. Pironi, A. Francavilla, F. W. Guglielmi

Research output: Contribution to journalArticle

Abstract

The investigation of critically ill patients reveals that parenteral nutrition (PN) is associated with a higher incidence of pneumonia, intra-abdominal abscess and possibly multiple organ dysfunction, than enteral nutrition. Extensive endocrine, metabolic and immunological changes occur in ICU patients, particularly those suffering from multiple injury, major burns, severe sepsis or severe inflammation. The purpose of this review will be first to describe briefly the gut dysfunction in critically ill patients and how gut dysfunction contributes to adverse outcomes. The discussion will then focus on additional harmful effects of TPN and on the potential therapeutic strategies to prevent and/or treat TPN-related digestive complications in these patients.

Original languageEnglish
Pages (from-to)86-98
Number of pages13
JournalNutritional Therapy and Metabolism
Volume24
Issue number2
Publication statusPublished - Apr 2006

Fingerprint

Critical Illness
digestive system
Abdominal Abscess
Multiple Trauma
Parenteral Nutrition
enteral feeding
Enteral Nutrition
abscess
parenteral feeding
Burns
pneumonia
Sepsis
Pneumonia
inflammation
Inflammation
incidence
therapeutics
Incidence
Therapeutics

Keywords

  • Critically Ill Patients
  • Total Parenteral Nutrition
  • TPN-Related Digestive Complications

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Anatomy
  • Nutrition and Dietetics
  • Food Science

Cite this

Forte, G., Bertinet, D. B., Federico, A., Guglielmi, A., Loguercio, C., Mazzuoli, S., ... Guglielmi, F. W. (2006). TPN-related digestive complications in critically ill patients. Nutritional Therapy and Metabolism, 24(2), 86-98.

TPN-related digestive complications in critically ill patients. / Forte, Giovambattista; Bertinet, D. Boggio; Federico, A.; Guglielmi, A.; Loguercio, C.; Mazzuoli, S.; Merli, M.; Palmo, A.; Panella, C.; Pironi, L.; Francavilla, A.; Guglielmi, F. W.

In: Nutritional Therapy and Metabolism, Vol. 24, No. 2, 04.2006, p. 86-98.

Research output: Contribution to journalArticle

Forte, G, Bertinet, DB, Federico, A, Guglielmi, A, Loguercio, C, Mazzuoli, S, Merli, M, Palmo, A, Panella, C, Pironi, L, Francavilla, A & Guglielmi, FW 2006, 'TPN-related digestive complications in critically ill patients', Nutritional Therapy and Metabolism, vol. 24, no. 2, pp. 86-98.
Forte G, Bertinet DB, Federico A, Guglielmi A, Loguercio C, Mazzuoli S et al. TPN-related digestive complications in critically ill patients. Nutritional Therapy and Metabolism. 2006 Apr;24(2):86-98.
Forte, Giovambattista ; Bertinet, D. Boggio ; Federico, A. ; Guglielmi, A. ; Loguercio, C. ; Mazzuoli, S. ; Merli, M. ; Palmo, A. ; Panella, C. ; Pironi, L. ; Francavilla, A. ; Guglielmi, F. W. / TPN-related digestive complications in critically ill patients. In: Nutritional Therapy and Metabolism. 2006 ; Vol. 24, No. 2. pp. 86-98.
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