Abstract
The investigation of critically ill patients reveals that parenteral nutrition (PN) is associated with a higher incidence of pneumonia, intra-abdominal abscess and possibly multiple organ dysfunction, than enteral nutrition. Extensive endocrine, metabolic and immunological changes occur in ICU patients, particularly those suffering from multiple injury, major burns, severe sepsis or severe inflammation. The purpose of this review will be first to describe briefly the gut dysfunction in critically ill patients and how gut dysfunction contributes to adverse outcomes. The discussion will then focus on additional harmful effects of TPN and on the potential therapeutic strategies to prevent and/or treat TPN-related digestive complications in these patients.
| Original language | English |
|---|---|
| Pages (from-to) | 86-98 |
| Number of pages | 13 |
| Journal | Nutritional Therapy and Metabolism |
| Volume | 24 |
| Issue number | 2 |
| Publication status | Published - Apr 2006 |
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Keywords
- Critically Ill Patients
- Total Parenteral Nutrition
- TPN-Related Digestive Complications
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
- Anatomy
- Nutrition and Dietetics
- Food Science
Cite this
TPN-related digestive complications in critically ill patients. / Forte, Giovambattista; Bertinet, D. Boggio; Federico, A.; Guglielmi, A.; Loguercio, C.; Mazzuoli, S.; Merli, M.; Palmo, A.; Panella, C.; Pironi, L.; Francavilla, A.; Guglielmi, F. W.
In: Nutritional Therapy and Metabolism, Vol. 24, No. 2, 04.2006, p. 86-98.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - TPN-related digestive complications in critically ill patients
AU - Forte, Giovambattista
AU - Bertinet, D. Boggio
AU - Federico, A.
AU - Guglielmi, A.
AU - Loguercio, C.
AU - Mazzuoli, S.
AU - Merli, M.
AU - Palmo, A.
AU - Panella, C.
AU - Pironi, L.
AU - Francavilla, A.
AU - Guglielmi, F. W.
PY - 2006/4
Y1 - 2006/4
N2 - The investigation of critically ill patients reveals that parenteral nutrition (PN) is associated with a higher incidence of pneumonia, intra-abdominal abscess and possibly multiple organ dysfunction, than enteral nutrition. Extensive endocrine, metabolic and immunological changes occur in ICU patients, particularly those suffering from multiple injury, major burns, severe sepsis or severe inflammation. The purpose of this review will be first to describe briefly the gut dysfunction in critically ill patients and how gut dysfunction contributes to adverse outcomes. The discussion will then focus on additional harmful effects of TPN and on the potential therapeutic strategies to prevent and/or treat TPN-related digestive complications in these patients.
AB - The investigation of critically ill patients reveals that parenteral nutrition (PN) is associated with a higher incidence of pneumonia, intra-abdominal abscess and possibly multiple organ dysfunction, than enteral nutrition. Extensive endocrine, metabolic and immunological changes occur in ICU patients, particularly those suffering from multiple injury, major burns, severe sepsis or severe inflammation. The purpose of this review will be first to describe briefly the gut dysfunction in critically ill patients and how gut dysfunction contributes to adverse outcomes. The discussion will then focus on additional harmful effects of TPN and on the potential therapeutic strategies to prevent and/or treat TPN-related digestive complications in these patients.
KW - Critically Ill Patients
KW - Total Parenteral Nutrition
KW - TPN-Related Digestive Complications
UR - http://www.scopus.com/inward/record.url?scp=34250726531&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34250726531&partnerID=8YFLogxK
M3 - Article
VL - 24
SP - 86
EP - 98
JO - Nutritional Therapy and Metabolism
JF - Nutritional Therapy and Metabolism
SN - 1828-6232
IS - 2
ER -