TPN-related digestive complications in critically ill patients

Giovambattista Forte, D. Boggio Bertinet, A. Federico, A. Guglielmi, C. Loguercio, S. Mazzuoli, M. Merli, A. Palmo, C. Panella, L. Pironi, A. Francavilla, F. W. Guglielmi

Research output: Contribution to journalArticlepeer-review


The investigation of critically ill patients reveals that parenteral nutrition (PN) is associated with a higher incidence of pneumonia, intra-abdominal abscess and possibly multiple organ dysfunction, than enteral nutrition. Extensive endocrine, metabolic and immunological changes occur in ICU patients, particularly those suffering from multiple injury, major burns, severe sepsis or severe inflammation. The purpose of this review will be first to describe briefly the gut dysfunction in critically ill patients and how gut dysfunction contributes to adverse outcomes. The discussion will then focus on additional harmful effects of TPN and on the potential therapeutic strategies to prevent and/or treat TPN-related digestive complications in these patients.

Original languageEnglish
Pages (from-to)86-98
Number of pages13
JournalNutritional Therapy and Metabolism
Issue number2
Publication statusPublished - Apr 2006


  • Critically Ill Patients
  • Total Parenteral Nutrition
  • TPN-Related Digestive Complications

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Anatomy
  • Nutrition and Dietetics
  • Food Science


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