TPT1/ TCTP-regulated pathways in phenotypic reprogramming

Robert Amson, Salvatore Pece, Jean Christophe Marine, Pier Paolo Di Fiore, Adam Telerman

Research output: Contribution to journalArticle

Abstract

Evolutionary conserved and pleiotropic, the TPT1/TCTP gene (translationally controlled tumor protein, also called HRF, fortilin), encodes a highly structured mRNA shielded by ribonucleoproteins and closely resembling viral particles. This mRNA activates, as do viruses, protein kinase R (PKR). The TPT1/TCTP protein is structurally similar to mRNA-helicases and MSS4. TPT1/TCTP has recently been identified as a prognostic factor in breast cancer and a critical regulator of the tumor suppressor p53 and of the cancer stem cell (SC) compartment. Emerging evidence indicates that TPT1/TCTP is key to phenotypic reprogramming, as shown in the process of tumor reversion and possibly in pluripotency. We provide here an overview of these diverse functions of TPT1/TCTP.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalTrends in Cell Biology
Volume23
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • MDM2
  • P53
  • Stem cells
  • Tumor reversion

ASJC Scopus subject areas

  • Cell Biology

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