Trabectedin for women with ovarian carcinoma after treatment with platinum and taxanes fails

Cristiana Sessa, Filippo De Braud, Antonella Perotti, Jean Bauer, Giuseppe Curigliano, Cristina Noberasco, Flavia Zanaboni, Luca Gianni, Silvia Marsoni, José Jimeno, Maurizio D'Incalci, Elisa Dall'ó, Nicoletta Colombo

Research output: Contribution to journalArticle

Abstract

Purpose: To assess the efficacy and toxicity of the marine-derived alkaloid trabectedin (ET-743) in patients with advanced ovarian cancer refractory to or experiencing disease relapse after platinum- and taxane-based chemotherapy. Patients and Methods: Fifty-nine patients from four institutions either resistant (n = 30) or sensitive (n = 29) to prior platinum and taxanes were treated with a 3-hour infusion of trabectedin every 3 weeks. Patients were monitored weekly for toxicity and restaged every two cycles for response. Response was assessed according to Response Evaluation Criteria in Solid Tumors Group. Results: The peer-reviewed objective response rate in platinum-sensitive patients was 43% (95% CI, 23% to 65%) with an estimated median time to progression of 7.9 months (95% CI, 7.5 to 14.1 months); in platinum-resistant patients two partial responses were observed. Responses were durable for up to 12.9 months (median, 5 months). The predominant toxicities at the recommended dose of 1,300 μg/m2 were neutropenia, asthenia, and self-limited increase of aminotransferases never requiring treatment interruption. Conclusion: Trabectedin administered as a 3-hour infusion at 1,300 μg/m 2 is a safe new drug with promising activity in relapsed ovarian cancer, showing a 43% objective response rate in patients with platinum-sensitive disease, which favorably compares with other salvage treatments and warrants additional development either alone or in combination.

Original languageEnglish
Pages (from-to)1867-1874
Number of pages8
JournalJournal of Clinical Oncology
Volume23
Issue number9
DOIs
Publication statusPublished - 2005

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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