Trabectedin in myxoid liposarcomas (MLS): A long-term analysis of a single-institution series

Federica Grosso, R. Sanfilippo, E. Virdis, C. Piovesan, P. Collini, P. Dileo, C. Morosi, J. C. Tercero, J. Jimeno, M. D'Incalci, A. Gronchi, S. Pilotti, P. G. Casali

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Trabectedin has been approved in Europe as second-line therapy for advanced soft tissue sarcomas. A previous analysis showed that myxoid liposarcomas (MLS) are particularly sensitive to the drug. We report on the long-term efficacy of trabectedin in a subgroup of that series. Methods: Since September 2002, 32 advanced pretreated MLS patients received trabectedin at our center. Data were reviewed focusing on their long-term outcome. Results: Trabectedin was given as a 24-h continuous infusion every 21 days. A total of 376 and a median of 12 courses per patient (range 2-26; interquartiles range (IQR) 8-15) were delivered. Response rate per RECIST was 50% [95% confidence interval (CI) 32% to 68%], median progression-free survival (PFS) was 17 months (95% CI 13.5-30.1) and median overall survival is still not reached. In 10 patients, therapy was stopped in the absence of any evident disease, mostly after complete surgery of residual lesions. In these 10 patients, at a median follow-up of 25 months, PFS was 28.1 months (95% CI 25.6-36.4) from treatment start. Discussion: These data indicate that the high response rate of MLS to trabectedin translates into prolonged PFS. Surgery of residual metastatic disease is already used quite extensively in metastatic MLS. Trabectedin may give further significance to this kind of surgery.

Original languageEnglish
Pages (from-to)1439-1444
Number of pages6
JournalAnnals of Oncology
Volume20
Issue number8
DOIs
Publication statusPublished - 2009

Keywords

  • Liposarcoma
  • Myxoid liposarcoma
  • Round-cell liposarcoma
  • Trabectedin

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Trabectedin in myxoid liposarcomas (MLS): A long-term analysis of a single-institution series'. Together they form a unique fingerprint.

Cite this