"Trabecular Bone Score" (TBS): An indirect measure of bone micro-architecture in postmenopausal patients with primary hyperparathyroidism

Elisabetta Romagnoli, Cristiana Cipriani, Italo Nofroni, Claudia Castro, Maurizio Angelozzi, Addolorata Scarpiello, Jessica Pepe, Daniele Diacinti, Sara Piemonte, Vincenzo Carnevale, Salvatore Minisola

Research output: Contribution to journalArticle

Abstract

Background: Patients with primary hyperparathyroidism (PHPT) generally show reduced bone mineral density (BMD) at cortical sites with relatively preserved trabecular bone. However, the increased fracture risk at all skeletal sites suggests that areal BMD probably is not effective in capturing all the determinants of bone strength. "Trabecular Bone Score" (TBS) has been recently proposed as an indirect measure of bone micro-architecture. Our study was aimed to investigate TBS in patients with PHPT. Methods: Seventy-three Caucasian postmenopausal women with PHPT and 74 age-matched healthy women (C) were studied. In all participants BMD at lumbar spine (LS) and at femoral sites (Neck-FN and total hip-TH) was measured by DXA and, in 67 patients and 34 C, also at the distal 1/3 of the radius (R). TBS was measured in the region of LS-BMD. Spine X ray was assessed in all patients. Results: Mean TBS values were significantly reduced in PHPT (1.19 ± 0.10) compared to C (1.24 ± 0.09, p. <0.01). Patients and controls did not differ for age, years since menopause (YSM), BMI, 25(OH)D serum levels, creatinine clearance, LS-BMD and FN-BMD. On the contrary, mean BMD values at both TH and R were significantly lower in PHPT patients compared to controls (p <0.01 and p <0.0001, respectively). In PHPT with vertebral fractures (VF. +, n = 29) TBS was significantly lower than in those without fracture (VF. -, n = 44)(1.14 ± 0.10 vs. 1.22 ± 0.10, respectively; p <0.01), whose TBS values did not differ from C. Mean TBS values in patients with (n = 18) and without (n = 55) non-vertebral fractures did not significantly differ (1.16 ± 0.09 vs. 1.20 ± 0.11). The presence of vertebral fractures was independently associated with the reduction of TBS (OR = 0.003, 95% CI = 0-0.534, p = 0.028) and with YSM (OR = 1.076, 95% CI = 1.017-1.139, p = 0.011), but not with age, the reduction of LS-BMD and the increase of BMI. The combination of YSM > 10. years plus TBS <1.2 was associated with a significant risk of VF (OR = 11.73, 95% CI 2.43-66.55, p <0.001). A TBS value <1.2 showed a better performance in individuating VF (sensibility 79.3%, specificity 61.4%, positive predictive value 57.5%, and negative predictive value 81.8%) in respect to YSM > 10. years. Conclusions: TBS seem. s to indirectly reflect an alteration of bone micro-architecture in postmenopausal women with PHPT.

Original languageEnglish
Pages (from-to)154-159
Number of pages6
JournalBone
Volume53
Issue number1
DOIs
Publication statusPublished - Mar 2013

Fingerprint

Primary Hyperparathyroidism
Bone and Bones
Bone Density
Spine
Lumbosacral Region
Femur Neck
Cancellous Bone
Hip
X-Rays

Keywords

  • "Trabecular Bone Score"
  • Bone mineral density
  • Primary hyperparathyroidism
  • Vertebral fractures

ASJC Scopus subject areas

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Histology

Cite this

Romagnoli, E., Cipriani, C., Nofroni, I., Castro, C., Angelozzi, M., Scarpiello, A., ... Minisola, S. (2013). "Trabecular Bone Score" (TBS): An indirect measure of bone micro-architecture in postmenopausal patients with primary hyperparathyroidism. Bone, 53(1), 154-159. https://doi.org/10.1016/j.bone.2012.11.041

"Trabecular Bone Score" (TBS) : An indirect measure of bone micro-architecture in postmenopausal patients with primary hyperparathyroidism. / Romagnoli, Elisabetta; Cipriani, Cristiana; Nofroni, Italo; Castro, Claudia; Angelozzi, Maurizio; Scarpiello, Addolorata; Pepe, Jessica; Diacinti, Daniele; Piemonte, Sara; Carnevale, Vincenzo; Minisola, Salvatore.

In: Bone, Vol. 53, No. 1, 03.2013, p. 154-159.

Research output: Contribution to journalArticle

Romagnoli, E, Cipriani, C, Nofroni, I, Castro, C, Angelozzi, M, Scarpiello, A, Pepe, J, Diacinti, D, Piemonte, S, Carnevale, V & Minisola, S 2013, '"Trabecular Bone Score" (TBS): An indirect measure of bone micro-architecture in postmenopausal patients with primary hyperparathyroidism', Bone, vol. 53, no. 1, pp. 154-159. https://doi.org/10.1016/j.bone.2012.11.041
Romagnoli, Elisabetta ; Cipriani, Cristiana ; Nofroni, Italo ; Castro, Claudia ; Angelozzi, Maurizio ; Scarpiello, Addolorata ; Pepe, Jessica ; Diacinti, Daniele ; Piemonte, Sara ; Carnevale, Vincenzo ; Minisola, Salvatore. / "Trabecular Bone Score" (TBS) : An indirect measure of bone micro-architecture in postmenopausal patients with primary hyperparathyroidism. In: Bone. 2013 ; Vol. 53, No. 1. pp. 154-159.
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keywords = "{"}Trabecular Bone Score{"}, Bone mineral density, Primary hyperparathyroidism, Vertebral fractures",
author = "Elisabetta Romagnoli and Cristiana Cipriani and Italo Nofroni and Claudia Castro and Maurizio Angelozzi and Addolorata Scarpiello and Jessica Pepe and Daniele Diacinti and Sara Piemonte and Vincenzo Carnevale and Salvatore Minisola",
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TY - JOUR

T1 - "Trabecular Bone Score" (TBS)

T2 - An indirect measure of bone micro-architecture in postmenopausal patients with primary hyperparathyroidism

AU - Romagnoli, Elisabetta

AU - Cipriani, Cristiana

AU - Nofroni, Italo

AU - Castro, Claudia

AU - Angelozzi, Maurizio

AU - Scarpiello, Addolorata

AU - Pepe, Jessica

AU - Diacinti, Daniele

AU - Piemonte, Sara

AU - Carnevale, Vincenzo

AU - Minisola, Salvatore

PY - 2013/3

Y1 - 2013/3

N2 - Background: Patients with primary hyperparathyroidism (PHPT) generally show reduced bone mineral density (BMD) at cortical sites with relatively preserved trabecular bone. However, the increased fracture risk at all skeletal sites suggests that areal BMD probably is not effective in capturing all the determinants of bone strength. "Trabecular Bone Score" (TBS) has been recently proposed as an indirect measure of bone micro-architecture. Our study was aimed to investigate TBS in patients with PHPT. Methods: Seventy-three Caucasian postmenopausal women with PHPT and 74 age-matched healthy women (C) were studied. In all participants BMD at lumbar spine (LS) and at femoral sites (Neck-FN and total hip-TH) was measured by DXA and, in 67 patients and 34 C, also at the distal 1/3 of the radius (R). TBS was measured in the region of LS-BMD. Spine X ray was assessed in all patients. Results: Mean TBS values were significantly reduced in PHPT (1.19 ± 0.10) compared to C (1.24 ± 0.09, p. <0.01). Patients and controls did not differ for age, years since menopause (YSM), BMI, 25(OH)D serum levels, creatinine clearance, LS-BMD and FN-BMD. On the contrary, mean BMD values at both TH and R were significantly lower in PHPT patients compared to controls (p <0.01 and p <0.0001, respectively). In PHPT with vertebral fractures (VF. +, n = 29) TBS was significantly lower than in those without fracture (VF. -, n = 44)(1.14 ± 0.10 vs. 1.22 ± 0.10, respectively; p <0.01), whose TBS values did not differ from C. Mean TBS values in patients with (n = 18) and without (n = 55) non-vertebral fractures did not significantly differ (1.16 ± 0.09 vs. 1.20 ± 0.11). The presence of vertebral fractures was independently associated with the reduction of TBS (OR = 0.003, 95% CI = 0-0.534, p = 0.028) and with YSM (OR = 1.076, 95% CI = 1.017-1.139, p = 0.011), but not with age, the reduction of LS-BMD and the increase of BMI. The combination of YSM > 10. years plus TBS <1.2 was associated with a significant risk of VF (OR = 11.73, 95% CI 2.43-66.55, p <0.001). A TBS value <1.2 showed a better performance in individuating VF (sensibility 79.3%, specificity 61.4%, positive predictive value 57.5%, and negative predictive value 81.8%) in respect to YSM > 10. years. Conclusions: TBS seem. s to indirectly reflect an alteration of bone micro-architecture in postmenopausal women with PHPT.

AB - Background: Patients with primary hyperparathyroidism (PHPT) generally show reduced bone mineral density (BMD) at cortical sites with relatively preserved trabecular bone. However, the increased fracture risk at all skeletal sites suggests that areal BMD probably is not effective in capturing all the determinants of bone strength. "Trabecular Bone Score" (TBS) has been recently proposed as an indirect measure of bone micro-architecture. Our study was aimed to investigate TBS in patients with PHPT. Methods: Seventy-three Caucasian postmenopausal women with PHPT and 74 age-matched healthy women (C) were studied. In all participants BMD at lumbar spine (LS) and at femoral sites (Neck-FN and total hip-TH) was measured by DXA and, in 67 patients and 34 C, also at the distal 1/3 of the radius (R). TBS was measured in the region of LS-BMD. Spine X ray was assessed in all patients. Results: Mean TBS values were significantly reduced in PHPT (1.19 ± 0.10) compared to C (1.24 ± 0.09, p. <0.01). Patients and controls did not differ for age, years since menopause (YSM), BMI, 25(OH)D serum levels, creatinine clearance, LS-BMD and FN-BMD. On the contrary, mean BMD values at both TH and R were significantly lower in PHPT patients compared to controls (p <0.01 and p <0.0001, respectively). In PHPT with vertebral fractures (VF. +, n = 29) TBS was significantly lower than in those without fracture (VF. -, n = 44)(1.14 ± 0.10 vs. 1.22 ± 0.10, respectively; p <0.01), whose TBS values did not differ from C. Mean TBS values in patients with (n = 18) and without (n = 55) non-vertebral fractures did not significantly differ (1.16 ± 0.09 vs. 1.20 ± 0.11). The presence of vertebral fractures was independently associated with the reduction of TBS (OR = 0.003, 95% CI = 0-0.534, p = 0.028) and with YSM (OR = 1.076, 95% CI = 1.017-1.139, p = 0.011), but not with age, the reduction of LS-BMD and the increase of BMI. The combination of YSM > 10. years plus TBS <1.2 was associated with a significant risk of VF (OR = 11.73, 95% CI 2.43-66.55, p <0.001). A TBS value <1.2 showed a better performance in individuating VF (sensibility 79.3%, specificity 61.4%, positive predictive value 57.5%, and negative predictive value 81.8%) in respect to YSM > 10. years. Conclusions: TBS seem. s to indirectly reflect an alteration of bone micro-architecture in postmenopausal women with PHPT.

KW - "Trabecular Bone Score"

KW - Bone mineral density

KW - Primary hyperparathyroidism

KW - Vertebral fractures

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