Abstract
Trace amines (TAs) act in the mammalian brain through amphetamine-like effects and as endogenous agonists of specific receptors. We now show that tyramine and β-phenylethylamine, in the presence of specific dopamine (DA) receptor antagonists, inhibit the GABAB-dependent presynaptic inhibition of GABAergic inputs to midbrain DA neurons. Our results further extend the role of TAs as neuromodulators and propose a novel mechanism by which they modulate DA neurons.
Original language | English |
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Pages (from-to) | 175-178 |
Number of pages | 4 |
Journal | Brain Research |
Volume | 1062 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - Nov 16 2005 |
Keywords
- GABAB
- Presynaptic mechanism
- Substantia nigra
- Trace amine
ASJC Scopus subject areas
- Neuroscience(all)