Trace amines reduce GABAB receptor-mediated presynaptic inhibition at GABAergic synapses of the rat substantia nigra pars compacta

Nicola Berretta; Michela Giustizieri; Giorgio Bernardi; Nicola B. Mercuri

doi:10.1016/j.brainres.2005.09.009

Trace amines reduce GABAB receptor-mediated presynaptic inhibition at GABAergic synapses of the rat substantia nigra pars compacta

Nicola Berretta, Michela Giustizieri, Giorgio Bernardi, Nicola B. Mercuri

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Trace amines (TAs) act in the mammalian brain through amphetamine-like effects and as endogenous agonists of specific receptors. We now show that tyramine and β-phenylethylamine, in the presence of specific dopamine (DA) receptor antagonists, inhibit the GABA_B-dependent presynaptic inhibition of GABAergic inputs to midbrain DA neurons. Our results further extend the role of TAs as neuromodulators and propose a novel mechanism by which they modulate DA neurons.

Original language	English
Pages (from-to)	175-178
Number of pages	4
Journal	Brain Research
Volume	1062
Issue number	1-2
DOIs	https://doi.org/10.1016/j.brainres.2005.09.009
Publication status	Published - Nov 16 2005

Keywords

GABAB
Presynaptic mechanism
Substantia nigra
Trace amine

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.brainres.2005.09.009

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abstract = "Trace amines (TAs) act in the mammalian brain through amphetamine-like effects and as endogenous agonists of specific receptors. We now show that tyramine and β-phenylethylamine, in the presence of specific dopamine (DA) receptor antagonists, inhibit the GABAB-dependent presynaptic inhibition of GABAergic inputs to midbrain DA neurons. Our results further extend the role of TAs as neuromodulators and propose a novel mechanism by which they modulate DA neurons.",

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AU - Berretta, Nicola

AU - Giustizieri, Michela

AU - Bernardi, Giorgio

AU - Mercuri, Nicola B.

PY - 2005/11/16

Y1 - 2005/11/16

N2 - Trace amines (TAs) act in the mammalian brain through amphetamine-like effects and as endogenous agonists of specific receptors. We now show that tyramine and β-phenylethylamine, in the presence of specific dopamine (DA) receptor antagonists, inhibit the GABAB-dependent presynaptic inhibition of GABAergic inputs to midbrain DA neurons. Our results further extend the role of TAs as neuromodulators and propose a novel mechanism by which they modulate DA neurons.

AB - Trace amines (TAs) act in the mammalian brain through amphetamine-like effects and as endogenous agonists of specific receptors. We now show that tyramine and β-phenylethylamine, in the presence of specific dopamine (DA) receptor antagonists, inhibit the GABAB-dependent presynaptic inhibition of GABAergic inputs to midbrain DA neurons. Our results further extend the role of TAs as neuromodulators and propose a novel mechanism by which they modulate DA neurons.

KW - GABAB

KW - Presynaptic mechanism

KW - Substantia nigra

KW - Trace amine

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Trace amines reduce GABAB receptor-mediated presynaptic inhibition at GABAergic synapses of the rat substantia nigra pars compacta

Abstract

Keywords

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