Trace amines reduce GABAB receptor-mediated presynaptic inhibition at GABAergic synapses of the rat substantia nigra pars compacta

Nicola Berretta, Michela Giustizieri, Giorgio Bernardi, Nicola B. Mercuri

Research output: Contribution to journalArticlepeer-review

Abstract

Trace amines (TAs) act in the mammalian brain through amphetamine-like effects and as endogenous agonists of specific receptors. We now show that tyramine and β-phenylethylamine, in the presence of specific dopamine (DA) receptor antagonists, inhibit the GABAB-dependent presynaptic inhibition of GABAergic inputs to midbrain DA neurons. Our results further extend the role of TAs as neuromodulators and propose a novel mechanism by which they modulate DA neurons.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalBrain Research
Volume1062
Issue number1-2
DOIs
Publication statusPublished - Nov 16 2005

Keywords

  • GABAB
  • Presynaptic mechanism
  • Substantia nigra
  • Trace amine

ASJC Scopus subject areas

  • Neuroscience(all)

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