Abstract
A high resolution headspace gas chromatography/selected ion monitoring analytical method has been developed for the quantitation of methanol in body fluids. The addition of tetradeuterated methanol as internal standard gives this method high accuracy and reproducibility. The high sensitivity of the mass spectrometer permits analysis of methanol in aqueous solutions at concentrations down to 0. 012 mg/l. The analytical procedure described was used to measure serum methanol in rats given 5 mg/kg of this alcohol orally. The method proved suitable for analysis of endogenous levels of methanol and of variations close to endogenous levels.
| Original language | English |
|---|---|
| Pages (from-to) | 113-116 |
| Number of pages | 4 |
| Journal | Journal of Chromatographic Science |
| Volume | 24 |
| Issue number | 3 |
| Publication status | Published - Mar 1986 |
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ASJC Scopus subject areas
- Clinical Biochemistry
- Analytical Chemistry
Cite this
Trace analysis of methanol in rat serum by headspace high resolution gas chromatography/selected ion monitoring. / Davoli, E.; Cappellini, L.; Airoldi, L.; Fanelli, R.
In: Journal of Chromatographic Science, Vol. 24, No. 3, 03.1986, p. 113-116.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Trace analysis of methanol in rat serum by headspace high resolution gas chromatography/selected ion monitoring
AU - Davoli, E.
AU - Cappellini, L.
AU - Airoldi, L.
AU - Fanelli, R.
PY - 1986/3
Y1 - 1986/3
N2 - A high resolution headspace gas chromatography/selected ion monitoring analytical method has been developed for the quantitation of methanol in body fluids. The addition of tetradeuterated methanol as internal standard gives this method high accuracy and reproducibility. The high sensitivity of the mass spectrometer permits analysis of methanol in aqueous solutions at concentrations down to 0. 012 mg/l. The analytical procedure described was used to measure serum methanol in rats given 5 mg/kg of this alcohol orally. The method proved suitable for analysis of endogenous levels of methanol and of variations close to endogenous levels.
AB - A high resolution headspace gas chromatography/selected ion monitoring analytical method has been developed for the quantitation of methanol in body fluids. The addition of tetradeuterated methanol as internal standard gives this method high accuracy and reproducibility. The high sensitivity of the mass spectrometer permits analysis of methanol in aqueous solutions at concentrations down to 0. 012 mg/l. The analytical procedure described was used to measure serum methanol in rats given 5 mg/kg of this alcohol orally. The method proved suitable for analysis of endogenous levels of methanol and of variations close to endogenous levels.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022681455&partnerID=8YFLogxK
M3 - Article
C2 - 3958112
AN - SCOPUS:0022681455
VL - 24
SP - 113
EP - 116
JO - Journal of Chromatographic Science
JF - Journal of Chromatographic Science
SN - 0021-9665
IS - 3
ER -