Trace elements, oxidative status and antioxidant capacity as biomarkers in very low birth weight infants

Beatrice Bocca, Simona Ciccarelli, Rocco Agostino, Alessandro Alimonti

Research output: Contribution to journalArticle

Abstract

Reference data on trace elements, oxidative status and antioxidants in very low birth weight infants (VLBW) are limited and need to be updated for use in clinical settings. Serum and urine of 30 VLBW infants (mean weight, 1167 g) at mean age of 23.8 (t0) and 37.8 (t1) days were analyzed. Cadmium (Cd), copper (Cu), iron (Fe), mercury (Hg), manganese (Mn), selenium (Se) and zinc (Zn), nitrate/nitrite (NOx), catalase (CAT), CuZnFeMn-superoxide dismutases (CuZnFeMn-SODs), total antioxidant capacity (SAC: sum of thiols, proteins, bilirubin, uric acid, β-beta-carotene, ascorbic acid, vitamin E) and total oxidative status (SOS: sum of lipo- and hydroperoxides) were determined. A higher urinary excretion of Cu and Zn was observed at t0 than at t1; while an increase in urine Cd was found at t1 respect to t0. A deficiency in serum levels of Cu and Zn was also found. A lower CAT activity, a higher total oxidants level (SOS) and a reduction of total antioxidant barriers (SAC) were observed in some infants. No Fe and Mn deficiency or Hg overload was found; also CuZnFeMn-SODs and NOx levels did not change. The findings showed that losses of trace elements and incomplete mineral body stores were more pronounced in the earlier life stage (at 23.8th day) than later on; moreover, antioxidant defenses were poor and lipo- and hydroperoxides were higher still at 5 weeks of infants’ life.

Original languageEnglish
Pages (from-to)705-713
Number of pages9
JournalEnvironmental Research
Volume156
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Very Low Birth Weight Infant
Trace Elements
Biomarkers
antioxidant
biomarker
Antioxidants
trace element
Lipid Peroxides
Manganese
Cadmium
Catalase
Hydrogen Peroxide
Superoxide Dismutase
zinc
Zinc
urine
Urine
serum
manganese
cadmium

Keywords

  • Antioxidant capacity
  • Oxidative stress
  • Tentative reference values
  • Trace elements
  • Very low birth weight infants

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this

Trace elements, oxidative status and antioxidant capacity as biomarkers in very low birth weight infants. / Bocca, Beatrice; Ciccarelli, Simona; Agostino, Rocco; Alimonti, Alessandro.

In: Environmental Research, Vol. 156, 01.01.2017, p. 705-713.

Research output: Contribution to journalArticle

Bocca, Beatrice ; Ciccarelli, Simona ; Agostino, Rocco ; Alimonti, Alessandro. / Trace elements, oxidative status and antioxidant capacity as biomarkers in very low birth weight infants. In: Environmental Research. 2017 ; Vol. 156. pp. 705-713.
@article{9c7d47b3c439462094b918cfb228abff,
title = "Trace elements, oxidative status and antioxidant capacity as biomarkers in very low birth weight infants",
abstract = "Reference data on trace elements, oxidative status and antioxidants in very low birth weight infants (VLBW) are limited and need to be updated for use in clinical settings. Serum and urine of 30 VLBW infants (mean weight, 1167 g) at mean age of 23.8 (t0) and 37.8 (t1) days were analyzed. Cadmium (Cd), copper (Cu), iron (Fe), mercury (Hg), manganese (Mn), selenium (Se) and zinc (Zn), nitrate/nitrite (NOx), catalase (CAT), CuZnFeMn-superoxide dismutases (CuZnFeMn-SODs), total antioxidant capacity (SAC: sum of thiols, proteins, bilirubin, uric acid, β-beta-carotene, ascorbic acid, vitamin E) and total oxidative status (SOS: sum of lipo- and hydroperoxides) were determined. A higher urinary excretion of Cu and Zn was observed at t0 than at t1; while an increase in urine Cd was found at t1 respect to t0. A deficiency in serum levels of Cu and Zn was also found. A lower CAT activity, a higher total oxidants level (SOS) and a reduction of total antioxidant barriers (SAC) were observed in some infants. No Fe and Mn deficiency or Hg overload was found; also CuZnFeMn-SODs and NOx levels did not change. The findings showed that losses of trace elements and incomplete mineral body stores were more pronounced in the earlier life stage (at 23.8th day) than later on; moreover, antioxidant defenses were poor and lipo- and hydroperoxides were higher still at 5 weeks of infants’ life.",
keywords = "Antioxidant capacity, Oxidative stress, Tentative reference values, Trace elements, Very low birth weight infants",
author = "Beatrice Bocca and Simona Ciccarelli and Rocco Agostino and Alessandro Alimonti",
year = "2017",
month = "1",
day = "1",
doi = "10.1016/j.envres.2017.04.027",
language = "English",
volume = "156",
pages = "705--713",
journal = "Environmental Research",
issn = "0013-9351",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Trace elements, oxidative status and antioxidant capacity as biomarkers in very low birth weight infants

AU - Bocca, Beatrice

AU - Ciccarelli, Simona

AU - Agostino, Rocco

AU - Alimonti, Alessandro

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Reference data on trace elements, oxidative status and antioxidants in very low birth weight infants (VLBW) are limited and need to be updated for use in clinical settings. Serum and urine of 30 VLBW infants (mean weight, 1167 g) at mean age of 23.8 (t0) and 37.8 (t1) days were analyzed. Cadmium (Cd), copper (Cu), iron (Fe), mercury (Hg), manganese (Mn), selenium (Se) and zinc (Zn), nitrate/nitrite (NOx), catalase (CAT), CuZnFeMn-superoxide dismutases (CuZnFeMn-SODs), total antioxidant capacity (SAC: sum of thiols, proteins, bilirubin, uric acid, β-beta-carotene, ascorbic acid, vitamin E) and total oxidative status (SOS: sum of lipo- and hydroperoxides) were determined. A higher urinary excretion of Cu and Zn was observed at t0 than at t1; while an increase in urine Cd was found at t1 respect to t0. A deficiency in serum levels of Cu and Zn was also found. A lower CAT activity, a higher total oxidants level (SOS) and a reduction of total antioxidant barriers (SAC) were observed in some infants. No Fe and Mn deficiency or Hg overload was found; also CuZnFeMn-SODs and NOx levels did not change. The findings showed that losses of trace elements and incomplete mineral body stores were more pronounced in the earlier life stage (at 23.8th day) than later on; moreover, antioxidant defenses were poor and lipo- and hydroperoxides were higher still at 5 weeks of infants’ life.

AB - Reference data on trace elements, oxidative status and antioxidants in very low birth weight infants (VLBW) are limited and need to be updated for use in clinical settings. Serum and urine of 30 VLBW infants (mean weight, 1167 g) at mean age of 23.8 (t0) and 37.8 (t1) days were analyzed. Cadmium (Cd), copper (Cu), iron (Fe), mercury (Hg), manganese (Mn), selenium (Se) and zinc (Zn), nitrate/nitrite (NOx), catalase (CAT), CuZnFeMn-superoxide dismutases (CuZnFeMn-SODs), total antioxidant capacity (SAC: sum of thiols, proteins, bilirubin, uric acid, β-beta-carotene, ascorbic acid, vitamin E) and total oxidative status (SOS: sum of lipo- and hydroperoxides) were determined. A higher urinary excretion of Cu and Zn was observed at t0 than at t1; while an increase in urine Cd was found at t1 respect to t0. A deficiency in serum levels of Cu and Zn was also found. A lower CAT activity, a higher total oxidants level (SOS) and a reduction of total antioxidant barriers (SAC) were observed in some infants. No Fe and Mn deficiency or Hg overload was found; also CuZnFeMn-SODs and NOx levels did not change. The findings showed that losses of trace elements and incomplete mineral body stores were more pronounced in the earlier life stage (at 23.8th day) than later on; moreover, antioxidant defenses were poor and lipo- and hydroperoxides were higher still at 5 weeks of infants’ life.

KW - Antioxidant capacity

KW - Oxidative stress

KW - Tentative reference values

KW - Trace elements

KW - Very low birth weight infants

UR - http://www.scopus.com/inward/record.url?scp=85018777921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018777921&partnerID=8YFLogxK

U2 - 10.1016/j.envres.2017.04.027

DO - 10.1016/j.envres.2017.04.027

M3 - Article

C2 - 28478178

AN - SCOPUS:85018777921

VL - 156

SP - 705

EP - 713

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

ER -