Abstract
During the last decade, the function/s of the cell membrane CD7 antigen have been investigated in human mature T and NK cells, showing the direct involvement of this molecule in multiple effector functions related with activation, proliferation, production of cytokines and modification of adhesion properties. The CD7 glycoprotein is not only expressed by mature lymphoid cells, but also by early hematopoietic progenitors and several types of leukemias, suggesting a role of CD7 during hematopoiesis. However, the function of CD7 in the early stages of hematopoietic development has not yet been elucidated. CD7 has been classically considered the earliest T-cell specific marker. This assumption was based on data indicating the presence of CD45+CD7+CD3-D4-CD8- cells in the human embryonic/fetal liver at the gestational age at which the thymic rudiment is colonized by T-cell progenitors. In the present article, we review recent results obtained by several groups concerning the expression of CD7 and various other cell surface antigens by T-, B- and myeloid-cell progenitors generated in the adult bone marrow and fetal liver. In addition, we present an hypothetical model of hematopoiesis in the fetal liver and thymus.
| Original language | English |
|---|---|
| Pages (from-to) | 1-11 |
| Number of pages | 11 |
| Journal | Leukemia and Lymphoma |
| Volume | 17 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 1995 |
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Keywords
- CD7
- Fetal bone marrow
- Fetal liver
- Fetal thymus
- Myeloid cell progenitors
- T-cell progenitors
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research
Cite this
Tracing the expression of CD7 and other antigens during t- and myeloid-cell differentiation in the human fetal liver and thymus. / Baarcenai, Alicia; Muench, Marcus O.; Roncarolo, Maria Grazia; Spits, Hergen.
In: Leukemia and Lymphoma, Vol. 17, No. 1-2, 1995, p. 1-11.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tracing the expression of CD7 and other antigens during t- and myeloid-cell differentiation in the human fetal liver and thymus
AU - Baarcenai, Alicia
AU - Muench, Marcus O.
AU - Roncarolo, Maria Grazia
AU - Spits, Hergen
PY - 1995
Y1 - 1995
N2 - During the last decade, the function/s of the cell membrane CD7 antigen have been investigated in human mature T and NK cells, showing the direct involvement of this molecule in multiple effector functions related with activation, proliferation, production of cytokines and modification of adhesion properties. The CD7 glycoprotein is not only expressed by mature lymphoid cells, but also by early hematopoietic progenitors and several types of leukemias, suggesting a role of CD7 during hematopoiesis. However, the function of CD7 in the early stages of hematopoietic development has not yet been elucidated. CD7 has been classically considered the earliest T-cell specific marker. This assumption was based on data indicating the presence of CD45+CD7+CD3-D4-CD8- cells in the human embryonic/fetal liver at the gestational age at which the thymic rudiment is colonized by T-cell progenitors. In the present article, we review recent results obtained by several groups concerning the expression of CD7 and various other cell surface antigens by T-, B- and myeloid-cell progenitors generated in the adult bone marrow and fetal liver. In addition, we present an hypothetical model of hematopoiesis in the fetal liver and thymus.
AB - During the last decade, the function/s of the cell membrane CD7 antigen have been investigated in human mature T and NK cells, showing the direct involvement of this molecule in multiple effector functions related with activation, proliferation, production of cytokines and modification of adhesion properties. The CD7 glycoprotein is not only expressed by mature lymphoid cells, but also by early hematopoietic progenitors and several types of leukemias, suggesting a role of CD7 during hematopoiesis. However, the function of CD7 in the early stages of hematopoietic development has not yet been elucidated. CD7 has been classically considered the earliest T-cell specific marker. This assumption was based on data indicating the presence of CD45+CD7+CD3-D4-CD8- cells in the human embryonic/fetal liver at the gestational age at which the thymic rudiment is colonized by T-cell progenitors. In the present article, we review recent results obtained by several groups concerning the expression of CD7 and various other cell surface antigens by T-, B- and myeloid-cell progenitors generated in the adult bone marrow and fetal liver. In addition, we present an hypothetical model of hematopoiesis in the fetal liver and thymus.
KW - CD7
KW - Fetal bone marrow
KW - Fetal liver
KW - Fetal thymus
KW - Myeloid cell progenitors
KW - T-cell progenitors
UR - http://www.scopus.com/inward/record.url?scp=0028898175&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028898175&partnerID=8YFLogxK
U2 - 10.3109/10428199509051697
DO - 10.3109/10428199509051697
M3 - Article
C2 - 7539656
AN - SCOPUS:0028898175
VL - 17
SP - 1
EP - 11
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
SN - 1042-8194
IS - 1-2
ER -