Tracing the mutated HTT and haplotype of the African ancestor who spread Huntington disease into the Middle East

Ferdinando Squitieri, Tommaso Mazza, Sabrina Maffi, Alessandro De Luca, Qasem AlSalmi, Salma AlHarasi, Jennifer A. Collins, Chris Kay, Fiona Baine-Savanhu, Bernard G. Landwhermeyer, Umberto Sabatini, Michael R. Hayden

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: We aimed to determine the origin and genetic characteristics of Huntington disease (HD) in the Middle East. Methods: We performed genetic and genealogical analyses to establish the ancestral origin of the HTT pathgenic variant from a large kindred from Oman (hereafter called the OM-HD-01 pedigree) by single-nucleotide polymorphism and dense haplotype analysis genotyping. Results: We traced the oldest ancestry of the largest, eight-generation, OM-HD-01 pedigree (n = 302 subjects, with 54 showing manifest HD) back to sub-Saharan Africa and identified a unique HD haplotype carried by all pedigree members, which consisted of portions of the C6 and C9 haplotypes and was carried by all affected members. Such a unique HD haplotype was of African origin and appeared to be associated with large CAG repeat expansions on average and high frequency of juvenile-onset HD. Three other families from the same area were also identified and found carrying a Caucasian HD haplotype A, also shared by most families of Arab ancestry. Conclusion: Mutated HTT spread into Middle East with a unique haplotype of African origin, appeared to be associated with juvenile-onset, a HD condition frequently occurring in Black Africans, and may have a significant impact on further development of novel targeted genetic therapies.

Original languageEnglish
Pages (from-to)1903-1908
Number of pages6
JournalGenetics in Medicine
Volume22
Issue number11
DOIs
Publication statusPublished - Nov 1 2020

Keywords

  • haplotype analysis
  • HTT
  • Huntington disease
  • juvenile-onset Huntington disease
  • SNP

ASJC Scopus subject areas

  • Genetics(clinical)

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