Tracking of indium-111-oxine labelled lymphocytes in autoimmune thyroid disease

P. Pozzilli, C. Pozzilli, P. Pantano, M. Negri, D. Andreani, A. G. Cudworth

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Peripheral lymphocytes (~ 108) from 4 subjects affected by autoimmune thyroid disease (2 Hashimoto's thyroiditis, 1 primary myxoedema, 1 Graves' disease) and 4 normal subjects were labelled in vitro with 40 μCi of indium-111-oxine and, following autologous injection, the distribution of the cells in the body was investigated by gamma camera imaging. Lymphocytes in the thyroid were observed 24 h after injection in both patients with Hashimoto's thyroiditis and in the patient with primary myxoedema, but not in the patient with Graves' disease or in any of the controls. To our knowledge, this is the first report using this method to try and demonstrate lymphocytes in the thyroid gland, and supports the concept that cell-mediated immunity may be playing an important role in the pathogenesis of Hashimoto's thyroiditis and primary myxoedema.

Original languageEnglish
Pages (from-to)111-116
Number of pages6
JournalClinical Endocrinology
Volume19
Issue number1
Publication statusPublished - 1983

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Myxedema
Hashimoto Disease
Thyroid Diseases
Autoimmune Diseases
Graves Disease
Lymphocytes
Thyroid Gland
Injections
Cellular Immunity
Radionuclide Imaging
indium oxine

ASJC Scopus subject areas

  • Endocrinology

Cite this

Pozzilli, P., Pozzilli, C., Pantano, P., Negri, M., Andreani, D., & Cudworth, A. G. (1983). Tracking of indium-111-oxine labelled lymphocytes in autoimmune thyroid disease. Clinical Endocrinology, 19(1), 111-116.

Tracking of indium-111-oxine labelled lymphocytes in autoimmune thyroid disease. / Pozzilli, P.; Pozzilli, C.; Pantano, P.; Negri, M.; Andreani, D.; Cudworth, A. G.

In: Clinical Endocrinology, Vol. 19, No. 1, 1983, p. 111-116.

Research output: Contribution to journalArticle

Pozzilli, P, Pozzilli, C, Pantano, P, Negri, M, Andreani, D & Cudworth, AG 1983, 'Tracking of indium-111-oxine labelled lymphocytes in autoimmune thyroid disease', Clinical Endocrinology, vol. 19, no. 1, pp. 111-116.
Pozzilli P, Pozzilli C, Pantano P, Negri M, Andreani D, Cudworth AG. Tracking of indium-111-oxine labelled lymphocytes in autoimmune thyroid disease. Clinical Endocrinology. 1983;19(1):111-116.
Pozzilli, P. ; Pozzilli, C. ; Pantano, P. ; Negri, M. ; Andreani, D. ; Cudworth, A. G. / Tracking of indium-111-oxine labelled lymphocytes in autoimmune thyroid disease. In: Clinical Endocrinology. 1983 ; Vol. 19, No. 1. pp. 111-116.
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