TY - JOUR
T1 - Traditional and non traditional risk factors in accelerated atherosclerosis in Systemic Lupus Erythematosus
T2 - Role of vascular endothelial growth factor (VEGATS Study)
AU - Colombo, Barbara Maria
AU - Cacciapaglia, Fabio
AU - Puntoni, Matteo
AU - Murdaca, Giuseppe
AU - Rossi, Edoardo
AU - Rodriguez, Guido
AU - Nobili, Flavio
AU - Pisciotta, Livia
AU - Bertolini, Stefano
AU - Moccetti, Tiziano
AU - Dentali, Francesco
AU - Steidl, Luigi
AU - Ciprandi, Giorgio
AU - Afeltra, Antonella
AU - Indiveri, Francesco
AU - Puppo, Francesco
PY - 2009/2
Y1 - 2009/2
N2 - Objective: To evaluate the role of vascular endothelial growth factor (VEGF) in accelerated atherosclerosis in patients with Systemic Lupus Erythematosus (SLE). Methods: We have enrolled 80 SLE female patients and 80 age-matched healthy control females who underwent a structured interview, physical examination, routine laboratory tests, VEGF plasma level determination and B-mode ultrasonography of carotid arteries to determine carotid intima media thickness (IMT). Framingham risk factors for cardiovascular events were also calculated and VEGF plasma levels were correlated with traditional and nontraditional cardiovascular risk factors. Results: SLE was significantly associated with higher mean IMT values (0.74 ± 0.15 mm versus 0.59 ±0.12 mm in controls, p <0.001) and higher mean plasma VEGF levels (307.9 ± 292.2 pg/mL versus 120.7 ± 118.4 pg/mL in controls, p <0.001) independently from age, smoking habits, and Framingham risk factors. A significant correlation was also found between IMT and VEGF values (r = 0.25; p <0.001). Conclusion: We show that SLE patients have increased mean IMT and VEGF values as compared with healthy age-matched controls and that IMT and VEGF values are independently and directly associated with SLE disease.
AB - Objective: To evaluate the role of vascular endothelial growth factor (VEGF) in accelerated atherosclerosis in patients with Systemic Lupus Erythematosus (SLE). Methods: We have enrolled 80 SLE female patients and 80 age-matched healthy control females who underwent a structured interview, physical examination, routine laboratory tests, VEGF plasma level determination and B-mode ultrasonography of carotid arteries to determine carotid intima media thickness (IMT). Framingham risk factors for cardiovascular events were also calculated and VEGF plasma levels were correlated with traditional and nontraditional cardiovascular risk factors. Results: SLE was significantly associated with higher mean IMT values (0.74 ± 0.15 mm versus 0.59 ±0.12 mm in controls, p <0.001) and higher mean plasma VEGF levels (307.9 ± 292.2 pg/mL versus 120.7 ± 118.4 pg/mL in controls, p <0.001) independently from age, smoking habits, and Framingham risk factors. A significant correlation was also found between IMT and VEGF values (r = 0.25; p <0.001). Conclusion: We show that SLE patients have increased mean IMT and VEGF values as compared with healthy age-matched controls and that IMT and VEGF values are independently and directly associated with SLE disease.
KW - Atherosclerosis
KW - Intima media thickness (IMT)
KW - Systemic Lupus Erythematosus (SLE)
KW - Vascular endothelial growth factor (VEGF)
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U2 - 10.1016/j.autrev.2008.10.002
DO - 10.1016/j.autrev.2008.10.002
M3 - Article
C2 - 18976721
AN - SCOPUS:61349192714
VL - 8
SP - 309
EP - 315
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
SN - 1568-9972
IS - 4
ER -