Traditional Serrated Adenomas on CT Colonography: International Multicenter Experience With This Rare Colorectal Neoplasm

Jeannine A Ruby, Laura Pusceddu, Andrew A Plumb, Seong Ho Park, David H Kim, Daniele Regge, Anmol Gangi, James Stephenson, Se Hyung Kim, Perry J Pickhardt

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE. Serrated polyps include hyperplastic polyps, sessile serrated polyps, and traditional serrated adenomas (TSAs). Hyperplastic polyps and sessile serrated polyps account for approximately 99% of all serrated lesions; TSAs are rare. However, both sessile serrated polyps and TSAs are now recognized as precursor lesions to carcinogenesis, representing approximately one-fourth of all sporadic colorectal cancers. We report what is, to our knowledge, the first series describing the characteristics of CTAs on CT colonography (CTC). MATERIALS AND METHODS. An international, multicenter, retrospective review of CT colonography-detected TSAs diagnosed between 2008 and 2018 was conducted. Data collected included patient demographics and data from CTC, optical colonoscopy, and pathologic analysis. RESULTS. A total of 67 proven TSAs in 58 patients (mean age, 67 years) were identified. The majority (66%) were located in the distal colon (descending colon, sigmoid colon, and rectum), and their mean size was 19 mm (range, 3-80 mm). Small (< 10 mm) TSAs typically had a simple sessile or pedunculated morphologic appearance, whereas large (≥ 10 mm) TSAs tended to be more lobulated and irregular, pedunculated, or carpetlike. The majority (88%) showed at least some contrast medium surface coating. CONCLUSION. We report what we believe to be the first multicenter experience describing the characteristics of TSAs on CTC. Unlike sessile serrated lesions, TSAs are more often left-sided and tend to be more lobulated and irregular. However, like sessile serrated polyps, most TSAs show contrast medium surface coating. Detection of these rare lesions on CTC is important, given their malignant potential.

Original languageEnglish
Pages (from-to)355-361
Number of pages7
JournalAmerican Journal of Roentgenology
Volume214
Issue number2
DOIs
Publication statusPublished - Feb 2020

Keywords

  • Adenoma/diagnostic imaging
  • Adult
  • Aged
  • Aged, 80 and over
  • Colonic Polyps/diagnostic imaging
  • Colonography, Computed Tomographic/methods
  • Colorectal Neoplasms/diagnostic imaging
  • Contrast Media
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies

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