Abstract
This review focuses on TNF-related apoptosis-inducing ligand (TRAIL), also called Apo2 ligand, a protein belonging to the TNF superfamily. TRAIL can be found either in its transmembrane or circulating form, and its mostly studied peripheral effect is the induction of cellular apoptosis. Here, we discuss the evidences supporting the use of TRAIL as biomarker of cardiovascular diseases as well as the evidences showing the potential beneficial therapeutic effects of TRAIL on cardiovascular diseases and diabetes.
| Original language | English |
|---|---|
| Pages (from-to) | 1215-1221 |
| Number of pages | 7 |
| Journal | Current Drug Targets |
| Volume | 13 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2012 |
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Keywords
- Cardiovascular diseases
- Diabetes
- TRAIL
ASJC Scopus subject areas
- Drug Discovery
- Pharmacology
- Clinical Biochemistry
- Molecular Medicine
Cite this
TRAIL as biomarker and potential therapeutic tool for cardiovascular diseases. / Bernardi, Stella; Milani, Daniela; Fabris, Bruno; Secchiero, Paola; Zauli, Giorgio.
In: Current Drug Targets, Vol. 13, No. 9, 2012, p. 1215-1221.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - TRAIL as biomarker and potential therapeutic tool for cardiovascular diseases
AU - Bernardi, Stella
AU - Milani, Daniela
AU - Fabris, Bruno
AU - Secchiero, Paola
AU - Zauli, Giorgio
PY - 2012
Y1 - 2012
N2 - This review focuses on TNF-related apoptosis-inducing ligand (TRAIL), also called Apo2 ligand, a protein belonging to the TNF superfamily. TRAIL can be found either in its transmembrane or circulating form, and its mostly studied peripheral effect is the induction of cellular apoptosis. Here, we discuss the evidences supporting the use of TRAIL as biomarker of cardiovascular diseases as well as the evidences showing the potential beneficial therapeutic effects of TRAIL on cardiovascular diseases and diabetes.
AB - This review focuses on TNF-related apoptosis-inducing ligand (TRAIL), also called Apo2 ligand, a protein belonging to the TNF superfamily. TRAIL can be found either in its transmembrane or circulating form, and its mostly studied peripheral effect is the induction of cellular apoptosis. Here, we discuss the evidences supporting the use of TRAIL as biomarker of cardiovascular diseases as well as the evidences showing the potential beneficial therapeutic effects of TRAIL on cardiovascular diseases and diabetes.
KW - Cardiovascular diseases
KW - Diabetes
KW - TRAIL
UR - http://www.scopus.com/inward/record.url?scp=84864552394&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864552394&partnerID=8YFLogxK
U2 - 10.2174/138945012802002357
DO - 10.2174/138945012802002357
M3 - Article
C2 - 22676911
AN - SCOPUS:84864552394
VL - 13
SP - 1215
EP - 1221
JO - Current Drug Targets
JF - Current Drug Targets
SN - 1389-4501
IS - 9
ER -