TRAIL as biomarker and potential therapeutic tool for cardiovascular diseases

Stella Bernardi, Daniela Milani, Bruno Fabris, Paola Secchiero, Giorgio Zauli

Research output: Contribution to journalArticlepeer-review

Abstract

This review focuses on TNF-related apoptosis-inducing ligand (TRAIL), also called Apo2 ligand, a protein belonging to the TNF superfamily. TRAIL can be found either in its transmembrane or circulating form, and its mostly studied peripheral effect is the induction of cellular apoptosis. Here, we discuss the evidences supporting the use of TRAIL as biomarker of cardiovascular diseases as well as the evidences showing the potential beneficial therapeutic effects of TRAIL on cardiovascular diseases and diabetes.

Original languageEnglish
Pages (from-to)1215-1221
Number of pages7
JournalCurrent Drug Targets
Volume13
Issue number9
DOIs
Publication statusPublished - 2012

Keywords

  • Cardiovascular diseases
  • Diabetes
  • TRAIL

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

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