TRAIL as biomarker and potential therapeutic tool for cardiovascular diseases

Stella Bernardi, Daniela Milani, Bruno Fabris, Paola Secchiero, Giorgio Zauli

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This review focuses on TNF-related apoptosis-inducing ligand (TRAIL), also called Apo2 ligand, a protein belonging to the TNF superfamily. TRAIL can be found either in its transmembrane or circulating form, and its mostly studied peripheral effect is the induction of cellular apoptosis. Here, we discuss the evidences supporting the use of TRAIL as biomarker of cardiovascular diseases as well as the evidences showing the potential beneficial therapeutic effects of TRAIL on cardiovascular diseases and diabetes.

Original languageEnglish
Pages (from-to)1215-1221
Number of pages7
JournalCurrent Drug Targets
Volume13
Issue number9
DOIs
Publication statusPublished - 2012

Fingerprint

TNF-Related Apoptosis-Inducing Ligand
Biomarkers
Cardiovascular Diseases
Therapeutic Uses
Therapeutics
Medical problems
Apoptosis
Ligands
Proteins

Keywords

  • Cardiovascular diseases
  • Diabetes
  • TRAIL

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Bernardi, S., Milani, D., Fabris, B., Secchiero, P., & Zauli, G. (2012). TRAIL as biomarker and potential therapeutic tool for cardiovascular diseases. Current Drug Targets, 13(9), 1215-1221. https://doi.org/10.2174/138945012802002357

TRAIL as biomarker and potential therapeutic tool for cardiovascular diseases. / Bernardi, Stella; Milani, Daniela; Fabris, Bruno; Secchiero, Paola; Zauli, Giorgio.

In: Current Drug Targets, Vol. 13, No. 9, 2012, p. 1215-1221.

Research output: Contribution to journalArticle

Bernardi, S, Milani, D, Fabris, B, Secchiero, P & Zauli, G 2012, 'TRAIL as biomarker and potential therapeutic tool for cardiovascular diseases', Current Drug Targets, vol. 13, no. 9, pp. 1215-1221. https://doi.org/10.2174/138945012802002357
Bernardi, Stella ; Milani, Daniela ; Fabris, Bruno ; Secchiero, Paola ; Zauli, Giorgio. / TRAIL as biomarker and potential therapeutic tool for cardiovascular diseases. In: Current Drug Targets. 2012 ; Vol. 13, No. 9. pp. 1215-1221.
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