Trait- and Frequency-Dependent Dysfunctional Habituation to Trigeminal Nociceptive Stimulation in Trigeminal Autonomic Cephalalgias

Armando Perrotta, Gianluca Coppola, Maria Grazia Anastasio, Roberto De Icco, Anna Ambrosini, Mariano Serrao, Vincenzo Parisi, Maurizio Evangelista, Giorgio Sandrini, Francesco Pierelli

Research output: Contribution to journalArticle

Abstract

We investigated whether the stimulation frequency (SF), the pain phases, and different diagnoses of trigeminal autonomic cephalalgias (TACs) may influence the habituation to pain. We studied the habituation of the nociceptive blink reflex R2 responses at different SFs (.05,.1,.2,.3,.5, and 1 Hz), in 28 episodic cluster headache (ECH) patients, 16 during and 12 outside the bout; they were compared with 16 episodic paroxysmal hemicrania (EPH) during the bout and 21 healthy subjects. We delivered 26 electrical stimuli and subdivided stimuli 2 to 26 in 5 blocks of 5 responses for each SF. Habituation values for each SF were expressed as the percentages of the mean area value of second through fifth blocks with respect to the first one. A significant lower mean percentage decrease of the R2 area across all blocks was found at.2 to 1 Hz SF during ECH, outside of the ECH, and EPH compared with healthy subjects. We showed a common frequency-dependent deficit of habituation of trigeminal nociceptive responses at higher SFs in ECH and EPH patients, independently from the disease phase. This abnormal temporal pattern of pain processing may suggest a trait-dependent dysfunction of some underlying pain-related subcortical structures, rather than a state-dependent functional abnormality due to the recurrence of the headache attacks during the active period. Perspective: TACs showed a frequency-related defective habituation of nociceptive trigeminal responses at the higher SFs, irrespectively of the diagnosis and/or the disease phase. We showed that the clinical similarities in the different subtypes of TACs are in parallel with a trait-dependent dysfunction in pain processing.

Original languageEnglish
Pages (from-to)1040-1048
Number of pages9
JournalJournal of Pain
Volume19
Issue number9
DOIs
Publication statusPublished - Sep 1 2018

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Trigeminal Autonomic Cephalalgias
Cluster Headache
Paroxysmal Hemicrania
Pain
Healthy Volunteers
Blinking
Headache
Recurrence

Keywords

  • Cluster headache
  • habituation
  • nociceptive blink reflex
  • paroxysmal hemicrania

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

Trait- and Frequency-Dependent Dysfunctional Habituation to Trigeminal Nociceptive Stimulation in Trigeminal Autonomic Cephalalgias. / Perrotta, Armando; Coppola, Gianluca; Anastasio, Maria Grazia; De Icco, Roberto; Ambrosini, Anna; Serrao, Mariano; Parisi, Vincenzo; Evangelista, Maurizio; Sandrini, Giorgio; Pierelli, Francesco.

In: Journal of Pain, Vol. 19, No. 9, 01.09.2018, p. 1040-1048.

Research output: Contribution to journalArticle

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AU - Anastasio, Maria Grazia

AU - De Icco, Roberto

AU - Ambrosini, Anna

AU - Serrao, Mariano

AU - Parisi, Vincenzo

AU - Evangelista, Maurizio

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AU - Pierelli, Francesco

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