The European Medicine Agency recommendations limiting codeine use in children have created a void in managing moderate pain. We review the evidence on the pharmacokinetic, pharmacodynamic and safety profile of tramadol, a possible substitute for codeine. Conclusion Tramadol appears to be safe in both paediatric inpatients and outpatients. It may be appropriate to limit the current use of tramadol to monitored settings in children with risk factors for respiratory depression, subject to further safety evidence.
|Number of pages||7|
|Journal||Acta Paediatrica, International Journal of Paediatrics|
|Publication status||Published - Nov 1 2014|
- Tramadol pharmacodinamic
- Tramadol pharmacokinetic
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health