Tramadol can selectively manage moderate pain in children following European advice limiting codeine use

Pierluigi Marzuillo, Lorenzo Calligaris, Egidio Barbi

Research output: Contribution to journalArticle

Abstract

The European Medicine Agency recommendations limiting codeine use in children have created a void in managing moderate pain. We review the evidence on the pharmacokinetic, pharmacodynamic and safety profile of tramadol, a possible substitute for codeine. Conclusion Tramadol appears to be safe in both paediatric inpatients and outpatients. It may be appropriate to limit the current use of tramadol to monitored settings in children with risk factors for respiratory depression, subject to further safety evidence.

Original languageEnglish
Pages (from-to)1110-1116
Number of pages7
JournalActa Paediatrica, International Journal of Paediatrics
Volume103
Issue number11
DOIs
Publication statusPublished - Nov 1 2014

Keywords

  • Codeine
  • Pain
  • Tramadol
  • Tramadol pharmacodinamic
  • Tramadol pharmacokinetic

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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