Tramesan, a novel polysaccharide from Trametes versicolor. Structural characterization and biological effects

Marzia Scarpari, Massimo Reverberi, Alessia Parroni, Valeria Scala, Corrado Fanelli, Chiara Pietricola, Slaven Zjalic, Vittoria Maresca, Agostino Tafuri, Maria R Ricciardi, Roberto Licchetta, Simone Mirabilii, Aris Sveronis, Paola Cescutti, Roberto Rizzo

Research output: Contribution to journalArticlepeer-review


Mushrooms represent a formidable source of bioactive compounds. Some of these may be considered as biological response modifiers; these include compounds with a specific biological function: antibiotics (e.g. plectasin), immune system stimulator (e,g, lentinan), antitumor agents (e.g. krestin, PSK) and hypolipidemic agents (e.g. lovastatin) inter alia. In this study, we focused on the Chinese medicinal mushroom "yun zhi", Trametes versicolor, traditionally used for (cit.) "replenish essence and qi (vital energy)". Previous studies indicated the potential activity of extracts from culture filtrate of asexual mycelia of T. versicolor in controlling the growth and secondary metabolism (e.g. mycotoxins) of plant pathogenic fungi. The quest of active principles produced by T. versicolor, allowed us characterising an exo-polysaccharide released in its culture filtrate and naming it Tramesan. Herein we evaluate the biological activity of Tramesan in different organisms: plants, mammals and plant pathogenic fungi. We suggest that the bioactivity of Tramesan relies mostly on its ability to act as pro antioxidant molecule regardless the biological system on which it was applied.

Original languageEnglish
Article numbere0171412
Number of pages22
JournalPLoS One
Issue number8
Publication statusPublished - Aug 22 2017


  • Carbohydrate Conformation
  • Chromatography, Gel
  • Magnetic Resonance Spectroscopy
  • Polysaccharides
  • Spectrometry, Mass, Electrospray Ionization
  • Trametes
  • Journal Article


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