Trans-arterial chemoembolization (TACE) of liver metastases from colorectal cancer using irinotecan-eluting beads: Preliminary results

Camillo Aliberti, M. Tilli, G. Benea, G. Fiorentini

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The purpose of the study was to evalutate the feasibility of irinotecan drug-eluting beads (DC Bead™) administered as trans-arterial chemoembolization (TACE) in patients with liver metastases from colorectal cancer (CRC). Patients and Methods: Ten patients with liver metastases from CRC were treated with TACE adopting irinotecan-eluting beads at a dose of 100 mg every 3 weeks. Computed Tomography (CT) was performed 24h before and after TACE. Results: TACE with irinotecan eluting beads was found to be feasible and well-tolerated. Right upper quadrant pain (RUQP) lasting 4 days (range 2-7) was reported by all the patients. After 30 days, a reduction >50% of CEA levels and of the lesional contrast enhancement was observed in all the patients. Conclusion: Irinotecan drug-eluting beads administered as TACE were shown to be active and safe in patients with liver metastases from CRC.

Original languageEnglish
Pages (from-to)3793-3795
Number of pages3
JournalAnticancer Research
Volume26
Issue number5 B
Publication statusPublished - Sep 2006

Keywords

  • Chemoembolization
  • Colorectal cancer
  • Drug-eluting beads
  • Irinotecan
  • Liver metastases

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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