Abstract
Purpose: The purpose of the study was to evalutate the feasibility of irinotecan drug-eluting beads (DC Bead™) administered as trans-arterial chemoembolization (TACE) in patients with liver metastases from colorectal cancer (CRC). Patients and Methods: Ten patients with liver metastases from CRC were treated with TACE adopting irinotecan-eluting beads at a dose of 100 mg every 3 weeks. Computed Tomography (CT) was performed 24h before and after TACE. Results: TACE with irinotecan eluting beads was found to be feasible and well-tolerated. Right upper quadrant pain (RUQP) lasting 4 days (range 2-7) was reported by all the patients. After 30 days, a reduction >50% of CEA levels and of the lesional contrast enhancement was observed in all the patients. Conclusion: Irinotecan drug-eluting beads administered as TACE were shown to be active and safe in patients with liver metastases from CRC.
| Original language | English |
|---|---|
| Pages (from-to) | 3793-3795 |
| Number of pages | 3 |
| Journal | Anticancer Research |
| Volume | 26 |
| Issue number | 5 B |
| Publication status | Published - Sep 2006 |
Keywords
- Chemoembolization
- Colorectal cancer
- Drug-eluting beads
- Irinotecan
- Liver metastases
ASJC Scopus subject areas
- Cancer Research
- Oncology