Trans-Synaptic Spread of Amyloid-in Alzheimer's Disease: Paths to-Amyloidosis

Annabella Pignataro, Silvia Middei

Research output: Contribution to journalReview articlepeer-review


Neuronal activity has a strong causal role in the production and release of the neurotoxicβ-amyloid peptide (Aβ). Because of this close link, gradual accumulation of Aβinto amyloid plaques has been reported in brain areas with intense neuronal activity, including cortical regions that display elevated activation at resting state. However, the link between Aβand activity is not always linear and recent studies report exceptions to the view of "more activity, more plaques." Here, we review the literature about the activity-dependent production of Aβin both human cases and AD models and focus on the evidences that brain regions with elevated convergence of synaptic connections (herein referred to as brain nodes) are particularly vulnerable to Aβaccumulation. Next, we will examine data supporting the hypothesis that, since Aβis released from synaptic terminals,β-amyloidosis can spread in AD brain by advancing through synaptically connected regions, which makes brain nodes vulnerable to Aβaccumulation. Finally, we consider possible mechanisms that account forβ-amyloidosis progression through synaptically linked regions.

Original languageEnglish
Pages (from-to)5281829
JournalNeural Plasticity
Publication statusPublished - 2017


  • Journal Article
  • Review


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