Transarterial chemoembolization plus sorafenib: A sequential therapeutic scheme for HCV-related intermediate-stage hepatocellular carcinoma: A randomized clinical trial

Domenico Sansonno, Gianfranco Lauletta, Sabino Russi, Vincenza Conteduca, Loredana Sansonno, Franco Dammacco

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Recurrence of hepatocellular carcinoma (HCC) is a major problem after surgical or ablative treatments. The aim of this prospective, single-center, placebocontrolled, randomized, double-blind clinical study was to evaluate the effectiveness of transarterial chemoembolization (TACE) combined with sorafenib as a sequential treatment regimen in delaying time to progression (TTP) of intermediate-stage HCC in patients with chronic hepatitis C virus (HCV) infection. Material and Methods. Between October, 2007 and January, 2011, 80 HCV-infected patients with Barcelona Clinic Liver Cancer stage B HCC underwent the TACE procedure. All had Child-Pugh class A disease. They were randomized 1:1 to receive sorafenib at a dose of 400 mg twice daily or placebo. Endpoints were the TTP and the rates of adverse events and toxicity. Results. Sixty-two of 80 patients (77%), 31 in the sorafenib group and 31 in the control group, completed the study. The median TTP was 9.2 months in the sorafenib group and 4.9 months in the placebo group (hazard ratio, 2.5; 95% confidence interval, 1.66-7.56; p

Original languageEnglish
Pages (from-to)359-366
Number of pages8
JournalThe oncologist
Volume17
Issue number3
DOIs
Publication statusPublished - 2012

Keywords

  • Hepatitis C virus
  • Hepatocellular carcinoma
  • Liver cirrhosis
  • Sorafenib
  • Time to progression

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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