Transarterial chemoembolization with drug-eluting beads preloaded with irinotecan as a first-line approach in uveal melanoma liver metastases: Tumor response and predictive value of diffusion-weighted MR imaging in five patients

Massimo Venturini, Lorenzo Pilla, Giulia Agostini, Stefano Cappio, Claudio Losio, Marcello Orsi, Francesca Ratti, Luca Aldrighetti, Francesco De Cobelli, Alessandro Del Maschio

Research output: Contribution to journalArticle

Abstract

Five patients with uveal melanoma metastatic to the liver (two to five lesions per patient) were prospectively enrolled and treated with transarterial chemoembolization with drug-eluting beads preloaded with irinotecan as a first-line therapy. An overall response rate of 80% was obtained per Response Evaluation Criteria In Solid Tumors. All patients were alive after mean follow-up durations of 10.6 months and 16.3 months, respectively, after the first treatment and the diagnosis of liver metastasis. The apparent diffusion coefficient values obtained by diffusion-weighted magnetic resonance imaging were significantly lower in lesions that showed a response. These findings are very promising and can constitute the background for further studies involving larger cohorts of patients.

Original languageEnglish
Pages (from-to)937-941
Number of pages5
JournalJournal of Vascular and Interventional Radiology
Volume23
Issue number7
DOIs
Publication statusPublished - Jul 2012

    Fingerprint

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this