TY - JOUR
T1 - Transarterial chemoembolization with drug-eluting beads preloaded with irinotecan as a first-line approach in uveal melanoma liver metastases
T2 - Tumor response and predictive value of diffusion-weighted MR imaging in five patients
AU - Venturini, Massimo
AU - Pilla, Lorenzo
AU - Agostini, Giulia
AU - Cappio, Stefano
AU - Losio, Claudio
AU - Orsi, Marcello
AU - Ratti, Francesca
AU - Aldrighetti, Luca
AU - De Cobelli, Francesco
AU - Del Maschio, Alessandro
PY - 2012/7
Y1 - 2012/7
N2 - Five patients with uveal melanoma metastatic to the liver (two to five lesions per patient) were prospectively enrolled and treated with transarterial chemoembolization with drug-eluting beads preloaded with irinotecan as a first-line therapy. An overall response rate of 80% was obtained per Response Evaluation Criteria In Solid Tumors. All patients were alive after mean follow-up durations of 10.6 months and 16.3 months, respectively, after the first treatment and the diagnosis of liver metastasis. The apparent diffusion coefficient values obtained by diffusion-weighted magnetic resonance imaging were significantly lower in lesions that showed a response. These findings are very promising and can constitute the background for further studies involving larger cohorts of patients.
AB - Five patients with uveal melanoma metastatic to the liver (two to five lesions per patient) were prospectively enrolled and treated with transarterial chemoembolization with drug-eluting beads preloaded with irinotecan as a first-line therapy. An overall response rate of 80% was obtained per Response Evaluation Criteria In Solid Tumors. All patients were alive after mean follow-up durations of 10.6 months and 16.3 months, respectively, after the first treatment and the diagnosis of liver metastasis. The apparent diffusion coefficient values obtained by diffusion-weighted magnetic resonance imaging were significantly lower in lesions that showed a response. These findings are very promising and can constitute the background for further studies involving larger cohorts of patients.
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U2 - 10.1016/j.jvir.2012.04.027
DO - 10.1016/j.jvir.2012.04.027
M3 - Article
C2 - 22720894
AN - SCOPUS:84862882661
VL - 23
SP - 937
EP - 941
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
SN - 1051-0443
IS - 7
ER -