Transbronchial Cryobiopsy in the Diagnosis of Diffuse Lung Disease

Alberto Cavazza, Thomas V. Colby, Alessandra Dubini, Sara Tomassetti, Claudia Ravaglia, Venerino Poletti, Maria Cecilia Mengoli, Elena Tagliavini, Giulio Rossi

Research output: Contribution to journalReview articlepeer-review


Transbronchial cryobiopsy, a new diagnostic procedure in patients with diffuse lung disease, provides larger and better-preserved lung specimens compared to forceps biopsy. The diagnostic yield of cryobiopsy is much better than that of forceps biopsy and slightly lower than that of surgical lung biopsy, but with a lower complication rate compared to the latter. Literature suggests that in the multidisciplinary approach to patients with diffuse lung disease cryobiopsy provides diagnostic and prognostic information similar to surgical lung biopsy. Cryobiopsy can also be performed in some patients unsuitable for surgical biopsy, yet in whom histologic input is needed.

Original languageEnglish
Pages (from-to)197-208
Number of pages12
JournalSurgical Pathology Clinics
Issue number1
Publication statusPublished - Mar 2020


  • Diffuse lung disease
  • Idiopathic pulmonary fibrosis
  • Interstitial lung disease
  • Multidisciplinary diagnosis
  • Nonspecific interstitial pneumonia
  • Transbronchial cryobiopsy
  • Usual interstitial pneumonia

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine


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