Transbronchial cryobiopsy in the diagnosis of fibrotic interstitial lung disease

Mitra Mehrad, Thomas V. Colby, Giulio Rossi, Alberto Cavazza

Research output: Contribution to journalArticlepeer-review


Context. - Transbronchial cryobiopsy is an emerging procedure to obtain lung tissue for diagnosis of interstitial lung disease and has gained popularity because it is less invasive and has a lower rate of complications compared with nonselective surgical lung biopsy. Objective. - To provide an overview of the status of the medical literature regarding transbronchial cryobiopsy. Data Sources. - A literature search was performed using PubMed search engine. The terms ''cryobiopsy'' or ''cryoprobe'' and ''interstitial lung disease'' or ''diffuse parenchymal lung disease'' or ''pulmonary fibrosis'' were used, with the search concluding at the end of November 2019. Conclusions. - While the diagnostic yield of transbronchial cryobiopsy is slightly lower than surgical lung biopsy, a growing amount of literature suggests that with a multidisciplinary approach cryobiopsy provides diagnostic and prognostic information approaching that of surgical lung biopsy with lower morbidity and mortality.

Original languageEnglish
Pages (from-to)1501-1508
Number of pages8
JournalArchives of Pathology and Laboratory Medicine
Issue number12
Publication statusPublished - Dec 2020

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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