Transcatheter Closure of Perimembranous Ventricular Septal Defects. Early and Long-Term Results

Gianfranco Butera, Mario Carminati, Massimo Chessa, Luciane Piazza, Angelo Micheletti, Diana Gabriella Negura, Raul Abella, Alessandro Giamberti, Alessandro Frigiola

Research output: Contribution to journalArticlepeer-review


Objectives: We sought to analyze safety, efficacy, and follow-up results of percutaneous closure of perimembranous ventricular septal defects (pmVSD). Background: Results of pmVSD transcatheter closure have been reported in the literature; however, follow-up data are still limited. Methods: Between January 1999 and June 2006, 104 patients underwent percutaneous closure of a pmVSD at our institution. An Amplatzer VSD device (muscular or eccentric) (AGA Medical Corp., Golden Valley, Minnesota) was used in all subjects. Results: The mean age at closure was 14 years (range 0.6 to 63 years). The attempt to place a device was successful in 100 patients (96.2%). The median device size used was 8 mm (range 4 to 16 mm). No deaths occurred. Total occlusion rate was 47% at completion of the procedure, rising to 84% at discharge and 99% during the follow-up. A total of 13 early complications occurred (11.5%), but in all but 2 subjects (1.9%) these were transient. The median follow-up was 38.5 months. The most significant complication was complete atrioventricular block (cAVB), which required pacemaker implantation in 6 subjects (5.7%; 2 in the early phase and 4 during the follow-up). Cox proportional hazards regression analysis showed that the only variable significantly associated with the occurrence of this complication was age at the time of the procedure (p = 0.028; relative risk 0.25). All subjects experiencing this problem were

Original languageEnglish
Pages (from-to)1189-1195
Number of pages7
JournalJournal of the American College of Cardiology
Issue number12
Publication statusPublished - Sep 18 2007

ASJC Scopus subject areas

  • Nursing(all)


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