Transcranial Direct Current Stimulation and Cerebral Vasomotor Reserve: A Study in Healthy Subjects

Elisa Giorli, Silvia Tognazzi, Lucia Briscese, Tommaso Bocci, Andrea Mazzatenta, Alberto Priori, Giovanni Orlandi, Massimo Del Sette, Ferdinando Sartucci

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND PURPOSE: Cerebral vasomotor reserve (VMR) is the capability of cerebral arterioles to change their diameter in response to various stimuli, such hypercapnia. Changes of VMR due to transcranial direct current stimulation (tDCS) have been poorly studied. METHODS: Twenty-five healthy subjects underwent anodal/cathodal and sham tDCS on right primary motor area. Before and after tDCS, we assessed VMR by Transcranial Color-Coded Sonography (TCCS) calculating trought Breath Holding Index (BHI) and Heart Rate Variability (HRV), in particular after Valsalva manouver. RESULTS: A-tDCS decreased VMR and BHI (p <0.05), whereas C-tDCS increased VMR, and BHI (p <0.05); Sham doesn't provide statistically significant of both VMR, BHI and HRV (p > 0.05). CONCLUSIONS: Our study confirms that tDCS induces a modification of bilateral VMR with a polarity-specific effect; based on this bilateral MFV and BHI modifications, we can speculate an involvement of the SNS in the VMR regulation.

Original languageEnglish
Pages (from-to)571-574
Number of pages4
JournalJournal of Neuroimaging
Volume25
Issue number4
DOIs
Publication statusPublished - Jul 1 2015

Fingerprint

Healthy Volunteers
Breath Holding
Valsalva Maneuver
Hypercapnia
Motor Cortex
Arterioles
Ultrasonography
Color
Heart Rate
Transcranial Direct Current Stimulation

Keywords

  • Carotid stenosis
  • Heart rate variability
  • TDCS
  • Vasomotor reserve

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Giorli, E., Tognazzi, S., Briscese, L., Bocci, T., Mazzatenta, A., Priori, A., ... Sartucci, F. (2015). Transcranial Direct Current Stimulation and Cerebral Vasomotor Reserve: A Study in Healthy Subjects. Journal of Neuroimaging, 25(4), 571-574. https://doi.org/10.1111/jon.12162

Transcranial Direct Current Stimulation and Cerebral Vasomotor Reserve : A Study in Healthy Subjects. / Giorli, Elisa; Tognazzi, Silvia; Briscese, Lucia; Bocci, Tommaso; Mazzatenta, Andrea; Priori, Alberto; Orlandi, Giovanni; Del Sette, Massimo; Sartucci, Ferdinando.

In: Journal of Neuroimaging, Vol. 25, No. 4, 01.07.2015, p. 571-574.

Research output: Contribution to journalArticle

Giorli, E, Tognazzi, S, Briscese, L, Bocci, T, Mazzatenta, A, Priori, A, Orlandi, G, Del Sette, M & Sartucci, F 2015, 'Transcranial Direct Current Stimulation and Cerebral Vasomotor Reserve: A Study in Healthy Subjects', Journal of Neuroimaging, vol. 25, no. 4, pp. 571-574. https://doi.org/10.1111/jon.12162
Giorli, Elisa ; Tognazzi, Silvia ; Briscese, Lucia ; Bocci, Tommaso ; Mazzatenta, Andrea ; Priori, Alberto ; Orlandi, Giovanni ; Del Sette, Massimo ; Sartucci, Ferdinando. / Transcranial Direct Current Stimulation and Cerebral Vasomotor Reserve : A Study in Healthy Subjects. In: Journal of Neuroimaging. 2015 ; Vol. 25, No. 4. pp. 571-574.
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