Transcranial direct current stimulation for the treatment of post-stroke depression in aphasic patients: a case series

Leandro Valiengo, Roberta Casati, Nadia Bolognini, Paulo A. Lotufo, Isabela M. Benseñor, Alessandra C. Goulart, André R. Brunoni

Research output: Contribution to journalArticle

Abstract

Aphasia is a common consequence of stroke; it is estimated that about two-thirds of aphasic patients will develop depression in the first year after the stroke. Treatment of post-stroke depression (PSD) is challenging due to the adverse effects of pharmacotherapy and difficulties in evaluating clinical outcomes, including aphasia. Transcranial direct current stimulation (tDCS) is a novel treatment that may improve clinical outcomes in the traditionally pharmacotherapy-refractory PSD. Our aim was to evaluate the safety and efficacy of tDCS for patients with PSD and with aphasia. The Stroke Aphasic Depression Questionnaire (SADQ) and the Aphasic Depression Rating Scale (ADRS) were used to evaluate the severity of PSD. The diagnoses of PSD and aphasia were confirmed by a psychiatrist and a speech-language pathologist, respectively. In this open case series, patients (n = 4) received 10 sessions (once a day) of bilateral tDCS to the dorsolateral prefrontal cortex (DLPFC) and two additional sessions after two and four weeks, for a total of 12 sessions. All patients exhibited improvement in depression after tDCS, as indicated by a decrease in SADQ (47.5%) and in ADRS (65.7%). This improvement was maintained four weeks after the treatment. In this preliminary, open-label study conducted in four PSD patients with aphasia, bilateral tDCS over the DLPFC was shown to induce a substantial mood improvement; tDCS was safe and well tolerated by every patient. Stroke patients with aphasia can be safely treated for PSD with tDCS. Sham-controlled studies are necessary to evaluate this technique further.

Original languageEnglish
Pages (from-to)225-228
Number of pages4
JournalNeurocase
Volume22
Issue number2
DOIs
Publication statusPublished - Mar 3 2016

Fingerprint

Stroke
Depression
Aphasia
Therapeutics
Prefrontal Cortex
Transcranial Direct Current Stimulation
Case Series
Stimulation
Aphasic
Drug Therapy
Psychiatry
Language
Safety

Keywords

  • aphasia
  • noninvasive brain stimulation
  • Post-stroke depression
  • stroke
  • tDCS

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Transcranial direct current stimulation for the treatment of post-stroke depression in aphasic patients : a case series. / Valiengo, Leandro; Casati, Roberta; Bolognini, Nadia; Lotufo, Paulo A.; Benseñor, Isabela M.; Goulart, Alessandra C.; Brunoni, André R.

In: Neurocase, Vol. 22, No. 2, 03.03.2016, p. 225-228.

Research output: Contribution to journalArticle

Valiengo, Leandro ; Casati, Roberta ; Bolognini, Nadia ; Lotufo, Paulo A. ; Benseñor, Isabela M. ; Goulart, Alessandra C. ; Brunoni, André R. / Transcranial direct current stimulation for the treatment of post-stroke depression in aphasic patients : a case series. In: Neurocase. 2016 ; Vol. 22, No. 2. pp. 225-228.
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