Transcranial direct current stimulation for treatment of freezing of gait: A cross-over study

Francesca Valentino, Giuseppe Cosentino, Filippo Brighina, Nicolò Gabriele Pozzi, Giorgio Sandrini, Brigida Fierro, Giovanni Savettieri, Marco D'Amelio, Claudio Pacchetti

Research output: Contribution to journalArticlepeer-review


Background and objective: Progression of Parkinson's disease (PD) is frequently characterized by the occurrence of freezing of gait (FOG) representing a disabling motor complication. We aim to investigate safety and efficacy of transcranial direct current stimulation of the primary motor cortex of PD patients with FOG. Methods: In this cross-over, double-blind, sham-controlled study, 10 PD patients with FOG persisting in "on" state underwent anodal and sham direct current stimulation for 5 consecutive days. Clinical assessment over a 1-month period was performed. Results: A significant improvement of gait, as assessed by the Stand Walk Sit test, with reduction in number and duration of FOG episodes, along with a significant reduction in the Unified Parkinson's Disease Rating Scale score, were observed after anodal stimulation. Beneficial effects were more evident after the entire 5-day stimulation session, and persisted until the end of the observation period. Conclusions: Anodal transcranial direct current stimulation of the motor cortex is safe and has therapeutic potential in PD patients with FOG.

Original languageEnglish
Pages (from-to)1064-1069
Number of pages6
JournalMovement Disorders
Issue number8
Publication statusPublished - 2014


  • Basal ganglia
  • Brain stimulation
  • Gait disorders
  • Motor cortex
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)


Dive into the research topics of 'Transcranial direct current stimulation for treatment of freezing of gait: A cross-over study'. Together they form a unique fingerprint.

Cite this