Transcranial direct current stimulation over the sensory-motor regions inhibits gamma synchrony

Giovanni Pellegrino, Giorgio Arcara, Giovanni Di Pino, Cristina Turco, Matteo Maran, Luca Weis, Francesco Piccione, Hartwig Roman Siebner

Research output: Contribution to journalArticle

Abstract

Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique able to induce plasticity phenomena. Although tDCS application has been spreading over a variety of neuroscience domains, the mechanisms by which the stimulation acts are largely unknown. We investigated tDCS effects on cortical gamma synchrony, which is a crucial player in cortical function. We performed a randomized, sham-controlled, double-blind study on healthy subjects, combining tDCS and magnetoencephalography. By driving brain activity via 40 Hz auditory stimulation during magnetoencephalography, we experimentally tuned cortical gamma synchrony and measured it before and after bilateral tDCS of the primary sensory-motor hand regions (anode left, cathode right). We demonstrated that the stimulation induces a remarkable decrease of gamma synchrony (13 out of 15 subjects), as measured by gamma phase at 40 Hz. tDCS has strong remote effects, as the cortical region mostly affected was located far away from the stimulation site and covered a large area of the right centro-temporal cortex. No significant differences between stimulations were found for baseline gamma synchrony, as well as early transient auditory responses. This suggests a specific tDCS effect on externally driven gamma synchronization. This study sheds new light on the effect of tDCS on cortical function showing that the net effect of the stimulation on cortical gamma synchronization is an inhibition.

Original languageEnglish
Pages (from-to)2736-2746
Number of pages11
JournalHuman Brain Mapping
Volume40
Issue number9
DOIs
Publication statusPublished - Jun 15 2019

Fingerprint

Magnetoencephalography
Electrodes
Cortical Synchronization
Acoustic Stimulation
Transcranial Direct Current Stimulation
Brain
Temporal Lobe
Neurosciences
Double-Blind Method
Healthy Volunteers
Hand
Inhibition (Psychology)

Cite this

Pellegrino, G., Arcara, G., Di Pino, G., Turco, C., Maran, M., Weis, L., ... Siebner, H. R. (2019). Transcranial direct current stimulation over the sensory-motor regions inhibits gamma synchrony. Human Brain Mapping, 40(9), 2736-2746. https://doi.org/10.1002/hbm.24556

Transcranial direct current stimulation over the sensory-motor regions inhibits gamma synchrony. / Pellegrino, Giovanni; Arcara, Giorgio; Di Pino, Giovanni; Turco, Cristina; Maran, Matteo; Weis, Luca; Piccione, Francesco; Siebner, Hartwig Roman.

In: Human Brain Mapping, Vol. 40, No. 9, 15.06.2019, p. 2736-2746.

Research output: Contribution to journalArticle

Pellegrino, Giovanni ; Arcara, Giorgio ; Di Pino, Giovanni ; Turco, Cristina ; Maran, Matteo ; Weis, Luca ; Piccione, Francesco ; Siebner, Hartwig Roman. / Transcranial direct current stimulation over the sensory-motor regions inhibits gamma synchrony. In: Human Brain Mapping. 2019 ; Vol. 40, No. 9. pp. 2736-2746.
@article{56bbd9cb7c4c47d1a8d38ce12771bac4,
title = "Transcranial direct current stimulation over the sensory-motor regions inhibits gamma synchrony",
abstract = "Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique able to induce plasticity phenomena. Although tDCS application has been spreading over a variety of neuroscience domains, the mechanisms by which the stimulation acts are largely unknown. We investigated tDCS effects on cortical gamma synchrony, which is a crucial player in cortical function. We performed a randomized, sham-controlled, double-blind study on healthy subjects, combining tDCS and magnetoencephalography. By driving brain activity via 40 Hz auditory stimulation during magnetoencephalography, we experimentally tuned cortical gamma synchrony and measured it before and after bilateral tDCS of the primary sensory-motor hand regions (anode left, cathode right). We demonstrated that the stimulation induces a remarkable decrease of gamma synchrony (13 out of 15 subjects), as measured by gamma phase at 40 Hz. tDCS has strong remote effects, as the cortical region mostly affected was located far away from the stimulation site and covered a large area of the right centro-temporal cortex. No significant differences between stimulations were found for baseline gamma synchrony, as well as early transient auditory responses. This suggests a specific tDCS effect on externally driven gamma synchronization. This study sheds new light on the effect of tDCS on cortical function showing that the net effect of the stimulation on cortical gamma synchronization is an inhibition.",
author = "Giovanni Pellegrino and Giorgio Arcara and {Di Pino}, Giovanni and Cristina Turco and Matteo Maran and Luca Weis and Francesco Piccione and Siebner, {Hartwig Roman}",
note = "{\circledC} 2019 Wiley Periodicals, Inc.",
year = "2019",
month = "6",
day = "15",
doi = "10.1002/hbm.24556",
language = "English",
volume = "40",
pages = "2736--2746",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "John Wiley and Sons Inc.",
number = "9",

}

TY - JOUR

T1 - Transcranial direct current stimulation over the sensory-motor regions inhibits gamma synchrony

AU - Pellegrino, Giovanni

AU - Arcara, Giorgio

AU - Di Pino, Giovanni

AU - Turco, Cristina

AU - Maran, Matteo

AU - Weis, Luca

AU - Piccione, Francesco

AU - Siebner, Hartwig Roman

N1 - © 2019 Wiley Periodicals, Inc.

PY - 2019/6/15

Y1 - 2019/6/15

N2 - Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique able to induce plasticity phenomena. Although tDCS application has been spreading over a variety of neuroscience domains, the mechanisms by which the stimulation acts are largely unknown. We investigated tDCS effects on cortical gamma synchrony, which is a crucial player in cortical function. We performed a randomized, sham-controlled, double-blind study on healthy subjects, combining tDCS and magnetoencephalography. By driving brain activity via 40 Hz auditory stimulation during magnetoencephalography, we experimentally tuned cortical gamma synchrony and measured it before and after bilateral tDCS of the primary sensory-motor hand regions (anode left, cathode right). We demonstrated that the stimulation induces a remarkable decrease of gamma synchrony (13 out of 15 subjects), as measured by gamma phase at 40 Hz. tDCS has strong remote effects, as the cortical region mostly affected was located far away from the stimulation site and covered a large area of the right centro-temporal cortex. No significant differences between stimulations were found for baseline gamma synchrony, as well as early transient auditory responses. This suggests a specific tDCS effect on externally driven gamma synchronization. This study sheds new light on the effect of tDCS on cortical function showing that the net effect of the stimulation on cortical gamma synchronization is an inhibition.

AB - Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique able to induce plasticity phenomena. Although tDCS application has been spreading over a variety of neuroscience domains, the mechanisms by which the stimulation acts are largely unknown. We investigated tDCS effects on cortical gamma synchrony, which is a crucial player in cortical function. We performed a randomized, sham-controlled, double-blind study on healthy subjects, combining tDCS and magnetoencephalography. By driving brain activity via 40 Hz auditory stimulation during magnetoencephalography, we experimentally tuned cortical gamma synchrony and measured it before and after bilateral tDCS of the primary sensory-motor hand regions (anode left, cathode right). We demonstrated that the stimulation induces a remarkable decrease of gamma synchrony (13 out of 15 subjects), as measured by gamma phase at 40 Hz. tDCS has strong remote effects, as the cortical region mostly affected was located far away from the stimulation site and covered a large area of the right centro-temporal cortex. No significant differences between stimulations were found for baseline gamma synchrony, as well as early transient auditory responses. This suggests a specific tDCS effect on externally driven gamma synchronization. This study sheds new light on the effect of tDCS on cortical function showing that the net effect of the stimulation on cortical gamma synchronization is an inhibition.

U2 - 10.1002/hbm.24556

DO - 10.1002/hbm.24556

M3 - Article

C2 - 30854728

VL - 40

SP - 2736

EP - 2746

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 9

ER -