Transcranial doppler assessment of the functional effects of symptomatic carotid stenosis

Mauro Silvestrini, E. Troisi, L. M. Cupini, M. Matteis, G. R. Pistolese, G. Bernardi

Research output: Contribution to journalArticle

Abstract

Mean flow velocity changes in the middle cerebral arteries (MCAs) during a 2-minute thumb-to-fin-ger opposition task were measured by means of transcranial Doppler ultrasonography in patients with severe unilateral carotid stenosis and ipsilateral transient ischemic attacks and in control subjects. The increase of flow velocity in the MCA contralateral to the hand performing the task was significantly different (p <0.001, one-way ANOVA) in controls (+5.52 ± 2.4 cm/sec) and in patients (+ 1.76 ± 1.6 cm/sec, side of stenosis; +3.83 ± 2.1 cm/sec, normal side). A post hoc least significant difference test revealed a significant difference between controls and patients on the side of stenosis (p <0.001) and between the normal side and the stenotic side in patients (p <0.03). One month after carotid endarterectomy, the effect of the motor task produced a significantly different effect on flow velocity in patients (p <0.01, two-way ANOYA) because the increase of flow velocity during the motor task on the side of stenosis (4.84 ± 1.9 cm/sec) was similar to that observed on the normal side (4.63 ± 1.4 cm/sec). These findings suggest that the effect of a simple motor task on flow velocity of MCAs may allow for the evaluation of the functional effects of carotid lesions. Prospective studies are needed to evaluate whether this test constitutes a useful approach for the identification of patients who would benefit from a surgical procedure.

Original languageEnglish
Pages (from-to)1910-1914
Number of pages5
JournalNeurology
Volume44
Issue number10
Publication statusPublished - 1994

Fingerprint

Carotid Stenosis
Middle Cerebral Artery
Pathologic Constriction
Doppler Transcranial Ultrasonography
Carotid Endarterectomy
Transient Ischemic Attack
Thumb
Analysis of Variance
Hand
Prospective Studies

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Silvestrini, M., Troisi, E., Cupini, L. M., Matteis, M., Pistolese, G. R., & Bernardi, G. (1994). Transcranial doppler assessment of the functional effects of symptomatic carotid stenosis. Neurology, 44(10), 1910-1914.

Transcranial doppler assessment of the functional effects of symptomatic carotid stenosis. / Silvestrini, Mauro; Troisi, E.; Cupini, L. M.; Matteis, M.; Pistolese, G. R.; Bernardi, G.

In: Neurology, Vol. 44, No. 10, 1994, p. 1910-1914.

Research output: Contribution to journalArticle

Silvestrini, M, Troisi, E, Cupini, LM, Matteis, M, Pistolese, GR & Bernardi, G 1994, 'Transcranial doppler assessment of the functional effects of symptomatic carotid stenosis', Neurology, vol. 44, no. 10, pp. 1910-1914.
Silvestrini M, Troisi E, Cupini LM, Matteis M, Pistolese GR, Bernardi G. Transcranial doppler assessment of the functional effects of symptomatic carotid stenosis. Neurology. 1994;44(10):1910-1914.
Silvestrini, Mauro ; Troisi, E. ; Cupini, L. M. ; Matteis, M. ; Pistolese, G. R. ; Bernardi, G. / Transcranial doppler assessment of the functional effects of symptomatic carotid stenosis. In: Neurology. 1994 ; Vol. 44, No. 10. pp. 1910-1914.
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