Abstract
Transcranial Doppler (TCD) recording was used to evaluate the mean flow velocity (MFV) and cerebrovascular reactivity to CO2 in 21 migraineurs during the interictal phase. Nine were affected by migraine with aura (MwA) and 12 by migraine without aura (MwoA). During each session the middle cerebral artery (MCA) flow velocity was examined in basal conditions, in hypocapnia after a 3-min period of hyperventilation, in basal conditions a second time, and in hypercapnia after breath-holding. The same procedure was followed in a group of 21 age-and sex-matched volunteers. Recordings were performed before (T1), during (T2), and after (T3) prophylactic treatment with flunarizine (10 mg/day for 2 months) to assess the possible effect of this drug on cerebral hemodynamics. In basal condition, increased MFV values were found in both MwA and MwoA patients. In MwA patients the reactivity index (RI) to hypocapnia was significantly increased in T1 (p
| Original language | English |
|---|---|
| Pages (from-to) | 492-496 |
| Number of pages | 5 |
| Journal | Cephalalgia |
| Volume | 19 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1999 |
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Keywords
- CO cerebrovascular reactivity
- Flunarizine
- MFV
- Migraine
- TCD
ASJC Scopus subject areas
- Clinical Neurology
Cite this
Transcranial Doppler evaluation of cerebral hemodynamics in migraineurs during prophylactic treatment with flunarizine. / Fiermonte, Giancarlo; Annulli, A.; Pierelli, F.
In: Cephalalgia, Vol. 19, No. 5, 1999, p. 492-496.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Transcranial Doppler evaluation of cerebral hemodynamics in migraineurs during prophylactic treatment with flunarizine
AU - Fiermonte, Giancarlo
AU - Annulli, A.
AU - Pierelli, F.
PY - 1999
Y1 - 1999
N2 - Transcranial Doppler (TCD) recording was used to evaluate the mean flow velocity (MFV) and cerebrovascular reactivity to CO2 in 21 migraineurs during the interictal phase. Nine were affected by migraine with aura (MwA) and 12 by migraine without aura (MwoA). During each session the middle cerebral artery (MCA) flow velocity was examined in basal conditions, in hypocapnia after a 3-min period of hyperventilation, in basal conditions a second time, and in hypercapnia after breath-holding. The same procedure was followed in a group of 21 age-and sex-matched volunteers. Recordings were performed before (T1), during (T2), and after (T3) prophylactic treatment with flunarizine (10 mg/day for 2 months) to assess the possible effect of this drug on cerebral hemodynamics. In basal condition, increased MFV values were found in both MwA and MwoA patients. In MwA patients the reactivity index (RI) to hypocapnia was significantly increased in T1 (p
AB - Transcranial Doppler (TCD) recording was used to evaluate the mean flow velocity (MFV) and cerebrovascular reactivity to CO2 in 21 migraineurs during the interictal phase. Nine were affected by migraine with aura (MwA) and 12 by migraine without aura (MwoA). During each session the middle cerebral artery (MCA) flow velocity was examined in basal conditions, in hypocapnia after a 3-min period of hyperventilation, in basal conditions a second time, and in hypercapnia after breath-holding. The same procedure was followed in a group of 21 age-and sex-matched volunteers. Recordings were performed before (T1), during (T2), and after (T3) prophylactic treatment with flunarizine (10 mg/day for 2 months) to assess the possible effect of this drug on cerebral hemodynamics. In basal condition, increased MFV values were found in both MwA and MwoA patients. In MwA patients the reactivity index (RI) to hypocapnia was significantly increased in T1 (p
KW - CO cerebrovascular reactivity
KW - Flunarizine
KW - MFV
KW - Migraine
KW - TCD
UR - http://www.scopus.com/inward/record.url?scp=0033064798&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033064798&partnerID=8YFLogxK
U2 - 10.1046/j.1468-2982.1999.019005492.x
DO - 10.1046/j.1468-2982.1999.019005492.x
M3 - Article
C2 - 10403064
AN - SCOPUS:0033064798
VL - 19
SP - 492
EP - 496
JO - Cephalalgia
JF - Cephalalgia
SN - 0333-1024
IS - 5
ER -