Transcranial Doppler evaluation of cerebral hemodynamics in migraineurs during prophylactic treatment with flunarizine

Giancarlo Fiermonte, A. Annulli, F. Pierelli

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Transcranial Doppler (TCD) recording was used to evaluate the mean flow velocity (MFV) and cerebrovascular reactivity to CO2 in 21 migraineurs during the interictal phase. Nine were affected by migraine with aura (MwA) and 12 by migraine without aura (MwoA). During each session the middle cerebral artery (MCA) flow velocity was examined in basal conditions, in hypocapnia after a 3-min period of hyperventilation, in basal conditions a second time, and in hypercapnia after breath-holding. The same procedure was followed in a group of 21 age-and sex-matched volunteers. Recordings were performed before (T1), during (T2), and after (T3) prophylactic treatment with flunarizine (10 mg/day for 2 months) to assess the possible effect of this drug on cerebral hemodynamics. In basal condition, increased MFV values were found in both MwA and MwoA patients. In MwA patients the reactivity index (RI) to hypocapnia was significantly increased in T1 (p

Original languageEnglish
Pages (from-to)492-496
Number of pages5
JournalCephalalgia
Volume19
Issue number5
DOIs
Publication statusPublished - 1999

Fingerprint

Flunarizine
Migraine with Aura
Hypocapnia
Migraine without Aura
Hemodynamics
Breath Holding
Hyperventilation
Hypercapnia
Middle Cerebral Artery
Volunteers
Therapeutics
Age Groups
Pharmaceutical Preparations

Keywords

  • CO cerebrovascular reactivity
  • Flunarizine
  • MFV
  • Migraine
  • TCD

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Transcranial Doppler evaluation of cerebral hemodynamics in migraineurs during prophylactic treatment with flunarizine. / Fiermonte, Giancarlo; Annulli, A.; Pierelli, F.

In: Cephalalgia, Vol. 19, No. 5, 1999, p. 492-496.

Research output: Contribution to journalArticle

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