Transcranial doppler sonography in the early phase of alzheimer’s disease

Sergio Bressi, M. A. Volontø, M. Alberoni, N. Canal, M. Franceschi

Research output: Contribution to journalArticle

Abstract

Transcranial Doppler sonography examination of 23 patients with Alzheimer's disease (AD) showed significantly slower blood fiow velocities, bilater- ally, in the middle cerebral arteries (MCAs) than in 10 healthy controls. The asymmetries of velocities in MCA were positively correlated with asymmetries of cognitive impairment, but not with global severity or duration of disease. Patients with prevalent left hemispheric neuropsychological dysfunction showed significantly slower blood flow in the left MCA, while the opposite pattern was observed in patients with prevalent right hemisphere dysfunction. The possibility that these findings are an expression of the reduction of cerebral blood flow and metabolism shown in AD by emission tomography studies is discussed.

Original languageEnglish
Pages (from-to)25-31
Number of pages7
JournalDementia and Geriatric Cognitive Disorders
Volume3
Issue number1
DOIs
Publication statusPublished - 1992

Keywords

  • Alzheimer’s disease
  • Cognition
  • Neuropsychology
  • Transcranial Doppler

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cognitive Neuroscience
  • Neuropsychology and Physiological Psychology

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